2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. 3,3'-Difluorobenzaldazine

3,3'-Difluorobenzaldazine  (Synonyms: DFB)

目录号: HY-14611 纯度: 99.44%
COA 产品使用指南

摩尔计算器

3,3'-Difluorobenzaldazine (DFB) 是一种选择性 mGluR5 正变构调节剂。3,3'-Difluorobenzaldazine 可增强 mGlu5 激动剂 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用，EC50 在 2 到 5 μM 范围内。

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3,3'-Difluorobenzaldazine Chemical Structure

3,3'-Difluorobenzaldazine Chemical Structure

CAS No. : 15332-10-2

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3,3'-Difluorobenzaldazine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-2 IC50
136 μM
Compound: DFB
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess assay
Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess assay
[PMID: 25937015]
BV-2 IC50
136 μM
Compound: DFB
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopolysaccharide stimulation and measured 24 hrs post lipopolysaccharide stimulation by Griess reagent assay
Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopolysaccharide stimulation and measured 24 hrs post lipopolysaccharide stimulation by Griess reagent assay
[PMID: 25801156]
CHO EC50
2.6 μM
Compound: 16
Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
Positive allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
[PMID: 25180768]
体外研究
(In Vitro)

3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC50 for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3,3'-Difluorobenzaldazine 相关抗体:
体内研究
(In Vivo)

3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI and ICR mice (8-9 weeks, 33-40 g)[2]
Dosage: 40-100 nmol (~9.7-24.4 μg)
Administration: ICV
Result: Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
分子量

244.24

Formula

C14H10F2N2
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (102.36 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0943 mL 20.4717 mL 40.9433 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

3,3'-Difluorobenzaldazine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0943 mL 20.4717 mL 40.9433 mL 102.3583 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL 20.4717 mL
10 mM 0.4094 mL 2.0472 mL 4.0943 mL 10.2358 mL
15 mM 0.2730 mL 1.3648 mL 2.7296 mL 6.8239 mL
20 mM 0.2047 mL 1.0236 mL 2.0472 mL 5.1179 mL
25 mM 0.1638 mL 0.8189 mL 1.6377 mL 4.0943 mL
30 mM 0.1365 mL 0.6824 mL 1.3648 mL 3.4119 mL
40 mM 0.1024 mL 0.5118 mL 1.0236 mL 2.5590 mL
50 mM 0.0819 mL 0.4094 mL 0.8189 mL 2.0472 mL
60 mM 0.0682 mL 0.3412 mL 0.6824 mL 1.7060 mL
80 mM 0.0512 mL 0.2559 mL 0.5118 mL 1.2795 mL
100 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0236 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,3'-Difluorobenzaldazine15332-10-2DFBmGluRMetabotropic glutamate receptorspotentiatelocomotorhyperactivityallostericmotorincoordinationcognitiveInhibitorinhibitorinhibit

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