3-(Methylthio)propionic acid (Synonyms: 3-Methylsulfanylpropionic acid)

目录号: HY-101401 纯度: 98.97%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

3-(Methylthio)propionic acid是甲硫氨酸代谢的中间体。

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3-(Methylthio)propionic acid Chemical Structure

CAS No. : 646-01-5

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥440	In-stock
100 mg	￥400	In-stock
200 mg		询价
500 mg		询价

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Methionine has consistently been shown to be the most toxic amino acid in experiments devised to assess the relative toxicity of dietary amino acids. 3-methylthiopropionate is an intermediate in methionine catabolism in rat and monkey liver in vitro. This pathway appears to account for a major portion of methionine oxidation in vitro^[1]. Cultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The first intermediate in the pathway may be the keto acid, which is then oxidatively decarboxylated to 3-methylthiopropionic acid^[2]. The purified 3-MTPA has antifungal activity in assays using F. oxysporum as a model fungus. Daily measurements of shoot and root length shows severe inhibition of seed germination and root and shoot development at concentrations above 12mg for partially purified extracts^[3]. 3-methylthiopropionic acid ethyl ester possesses potential anticarcinogenic properties by inducing differentiation in well-differentiated colon cancer cells. Treatment of RCM-1 cells for 4 days with 3-methylthiopropionic acid ethyl ester between the doses of 0.25 and 2 mM progressively increases the percent area occupied by duct structures relative to the control, and also induces an increase in the number and the maximum diameter of the ducts in each culture plate^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

120.17

Formula

C₄H₈O₂S

CAS 号

646-01-5

性状

液体（密度：1.160 g/cm³）

颜色

Colorless to light yellow

中文名称

3-甲基硫代丙酸；3-(甲基硫代)丙酸

结构分类

Ketones, Aldehydes, Acids

初始来源

微生物

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 250 mg/mL (2080.39 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : 25 mg/mL (208.04 mM; 超声助溶)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	8.3215 mL	41.6077 mL	83.2154 mL
5 mM	1.6643 mL	8.3215 mL	16.6431 mL
10 mM	0.8322 mL	4.1608 mL	8.3215 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (832.15 mM); 澄清溶液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 98.97%

选择批次：

Data Sheet (609 KB) SDS (416 KB)

COA (188 KB) HNMR (237 KB) LCMS (88 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Steele RD, et al. Identification of 3-methylthiopropionic acid as an intermediate in mammalian methioninemetabolism in vitro. J Biol Chem. 1978 Nov 10;253(21):7844-50. [Content Brief]

[2]. Surette R, et al. Formation of 3-methylthioacrylic acid from methionine by Streptomyces lincolnensis. Isolation of a peroxidase. J Antibiot (Tokyo). 1976 Jun;29(6):646-52. [Content Brief]

[3]. Kim YC, et al. 3-methylthiopropanoic acid produced by Enterobacter intermedium 60-2G inhibits fungal growth and weed seedling development. J Antibiot (Tokyo). 2003 Feb;56(2):177-80. [Content Brief]

[4]. Nakamura Y, et al. 3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells. J Agric Food Chem. 2008 May 14;56(9):2977-84. [Content Brief]

Cell Assay ^[4]	RCM-1 cells are each plated into 35-mm plastic culture plates. Twenty-four hours after plating, cells are treated with 3-methylthiopropionic acid ethyl ester in 2 mL of 10% FBS-RPMI+F12 for 4 days, and are counted by using a hemacytometer, after trypsinization with 0.25% trypsin and 1 mM EDTA^[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Steele RD, et al. Identification of 3-methylthiopropionic acid as an intermediate in mammalian methioninemetabolism in vitro. J Biol Chem. 1978 Nov 10;253(21):7844-50. [Content Brief] [2]. Surette R, et al. Formation of 3-methylthioacrylic acid from methionine by Streptomyces lincolnensis. Isolation of a peroxidase. J Antibiot (Tokyo). 1976 Jun;29(6):646-52. [Content Brief] [3]. Kim YC, et al. 3-methylthiopropanoic acid produced by Enterobacter intermedium 60-2G inhibits fungal growth and weed seedling development. J Antibiot (Tokyo). 2003 Feb;56(2):177-80. [Content Brief] [4]. Nakamura Y, et al. 3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells. J Agric Food Chem. 2008 May 14;56(9):2977-84. [Content Brief]

Cell Assay
^[4]

RCM-1 cells are each plated into 35-mm plastic culture plates. Twenty-four hours after plating, cells are treated with 3-methylthiopropionic acid ethyl ester in 2 mL of 10% FBS-RPMI+F12 for 4 days, and are counted by using a hemacytometer, after trypsinization with 0.25% trypsin and 1 mM EDTA^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Steele RD, et al. Identification of 3-methylthiopropionic acid as an intermediate in mammalian methioninemetabolism in vitro. J Biol Chem. 1978 Nov 10;253(21):7844-50. [Content Brief]

[2]. Surette R, et al. Formation of 3-methylthioacrylic acid from methionine by Streptomyces lincolnensis. Isolation of a peroxidase. J Antibiot (Tokyo). 1976 Jun;29(6):646-52. [Content Brief]

[3]. Kim YC, et al. 3-methylthiopropanoic acid produced by Enterobacter intermedium 60-2G inhibits fungal growth and weed seedling development. J Antibiot (Tokyo). 2003 Feb;56(2):177-80. [Content Brief]

[4]. Nakamura Y, et al. 3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells. J Agric Food Chem. 2008 May 14;56(9):2977-84. [Content Brief]

3-(Methylthio)propionic acid 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	8.3215 mL	41.6077 mL	83.2154 mL	208.0386 mL
	5 mM	1.6643 mL	8.3215 mL	16.6431 mL	41.6077 mL
	10 mM	0.8322 mL	4.1608 mL	8.3215 mL	20.8039 mL
	15 mM	0.5548 mL	2.7738 mL	5.5477 mL	13.8692 mL
	20 mM	0.4161 mL	2.0804 mL	4.1608 mL	10.4019 mL
	25 mM	0.3329 mL	1.6643 mL	3.3286 mL	8.3215 mL
	30 mM	0.2774 mL	1.3869 mL	2.7738 mL	6.9346 mL
	40 mM	0.2080 mL	1.0402 mL	2.0804 mL	5.2010 mL
	50 mM	0.1664 mL	0.8322 mL	1.6643 mL	4.1608 mL
	60 mM	0.1387 mL	0.6935 mL	1.3869 mL	3.4673 mL
	80 mM	0.1040 mL	0.5201 mL	1.0402 mL	2.6005 mL
	100 mM	0.0832 mL	0.4161 mL	0.8322 mL	2.0804 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-(Methylthio)propionic acid646-01-53-Methylsulfanylpropionic acid3-甲基硫代丙酸3-(甲基硫代)丙酸FungalEndogenous MetaboliteInhibitorinhibitorinhibit

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

3-(Methylthio)propionic acid (Synonyms: 3-Methylsulfanylpropionic acid)

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