2. 天然产物
  3. 疾病研究领域 植物 生物碱
  4. 毛茛科 癌症 异喹啉类生物碱
  5. 黄连
  6. 8-Oxocoptisine

8-Oxocoptisine  (Synonyms: 8-氧黄连碱)

目录号: HY-N8346 纯度: 99.94%
COA 产品使用指南

摩尔计算器

8-Oxocoptisine 是一种天然原小檗碱生物碱，具有抗癌活性。

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8-Oxocoptisine Chemical Structure

8-Oxocoptisine Chemical Structure

CAS No. : 19716-61-1

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥2800
In-stock
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Customer Review

8-Oxocoptisine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
GES1 IC50
> 150 μM
Compound: 5
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 35286954]
HGC-27 IC50
54.6 μM
Compound: 5
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 35286954]
IEC-6 EC50
0.0798 μM
Compound: 2; 8-ODC
Activation of XBP1 in rat IEC-6 cells assessed as transcriptional activity measured after 48 hrs by dual luciferase reporter gene assay
Activation of XBP1 in rat IEC-6 cells assessed as transcriptional activity measured after 48 hrs by dual luciferase reporter gene assay
[PMID: 26981782]
MGC-803 IC50
61.5 μM
Compound: 5
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 35286954]
体外研究
(In Vitro)

8-Oxocoptisine has cytotoxicity against NCI-N87 (IC50=20.31 μM) and has no cytotoxicity against Caco-2 (IC50>100 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-Oxocoptisine 相关抗体:
分子量

335.31

Formula

C19H13NO5
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

8-氧黄连碱；8-氧代黄连碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2.08 mg/mL (6.20 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9823 mL 14.9116 mL 29.8231 mL
5 mM 0.5965 mL 2.9823 mL 5.9646 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.94%

COA (198 KB) HNMR (101 KB) RP-HPLC (301 KB)

产品使用指南 (1538 KB)
参考文献

8-Oxocoptisine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9823 mL 14.9116 mL 29.8231 mL 74.5579 mL
5 mM 0.5965 mL 2.9823 mL 5.9646 mL 14.9116 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Oxocoptisine19716-61-18-氧黄连碱8-氧代黄连碱OthersInhibitorinhibitorinhibit

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目录号：
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