Galidesivir (Synonyms: BCX4430; Immucillin-A)

目录号: HY-18649A 纯度: 99.13%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Galidesivir (BCX4430)，一种腺苷类似物和直接作用的抗病毒活性分子，能破坏病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 活性。Galidesivir 在体外对多种 RNA 病毒病原体具有活性，包括丝状病毒和新兴的感染因子，如 MERS-CoV、SARS-CoV 和 SARS-CoV-2。Galidesivir 对一些负义 RNA 病毒的 EC₅₀ 在 ~3 到 ~68 μM。

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Galidesivir Chemical Structure

CAS No. : 249503-25-1

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规格	价格	是否有货
10 mM * 1 mL in Water	￥5836	In-stock
1 mg	￥2000	In-stock
5 mg	￥6000	In-stock
10 mg	现货	询价
50 mg		询价
100 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

Other Forms of Galidesivir:

Galidesivir hydrochloride In-stock
Galidesivir dihydrochloride 询价

MCE 顾客使用本产品发表的 8 篇科研文献

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生物活性
纯度 & 产品资料
参考文献

生物活性

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC₅₀s ranging from ~3 to ~68 μM^[1]^[2]^[3].

IC₅₀ & Target

RdRp

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Huh-7	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Huh-7	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by visual analysis Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Huh-7	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by visual assay Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by visual assay	[PMID: 37077387]
MDCK	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
MDCK	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by visual analysis Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
RD	EC₅₀	3.8 μg/mL Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
RD	EC₅₀	3.8 μg/mL Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Vero	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by visual assay Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by visual assay	[PMID: 37077387]
Vero	EC₅₀	3.8 μg/mL Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero	EC₅₀	3.8 μg/mL Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero	EC₅₀	3.8 μg/mL Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero 76	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Vero 76	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by neutral red dye based analysis Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by neutral red dye based analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 μM Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by visual analysis	[PMID: 37077387]

体外研究
(In Vitro)

加利地西韦能有效抑制黄热病毒对Vero细胞的感染，中性红摄取试验测定的EC50为8.3 μg/ml (24.5 μM)^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Galidesivir (BCX4430) 在肌内、腹膜内和口服给药后在多种实验性感染中具有活性。在涉及埃博拉病毒、马尔堡病毒、裂谷热病毒和黄热病病毒的致死性感染的非临床研究中，Galidesivir 显示出显著的疗效^[1]。
Galidesivir (4 mg/kg；腹腔注射；每天两次，持续 7 天) 在黄热病 (YF) 仓鼠模型中有效^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Syrian golden hamsters (hamsters infected with YF virus)^[4]
Dosage:	4 mg/kg of body weight
Administration:	I.p.; twice daily for 7 days
Result:	Significantly improved the survival of hamsters infected with YFV.

Clinical Trial

分子量

265.27

Formula

C₁₁H₁₅N₅O₃

CAS 号

249503-25-1

性状

固体

颜色

White to off-white

中文名称

加利司韦；加利地韦

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

H₂O 中的溶解度 : 100 mg/mL (376.97 mM; 超声助溶)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7697 mL	18.8487 mL	37.6974 mL
5 mM	0.7539 mL	3.7697 mL	7.5395 mL
10 mM	0.3770 mL	1.8849 mL	3.7697 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 99.29%

选择批次：

Data Sheet (626 KB) SDS (393 KB)

COA (291 KB) HNMR (185 KB) LCMS (241 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Taylor R, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016;9(3):220-226. [Content Brief]

[2]. Elfiky AA, et al. ICN-1229, Remdesivir, PSI-7977, Galidesivir, and GS 1278 against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 2020 Mar 25:117592. [Content Brief]

[3]. Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014;508(7496):402-405. [Content Brief]

[4]. Julander JG, et al. BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model. Antimicrob Agents Chemother. 2014;58(11):6607-6614. [Content Brief]

Galidesivir 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7697 mL	18.8487 mL	37.6974 mL	94.2436 mL
	5 mM	0.7539 mL	3.7697 mL	7.5395 mL	18.8487 mL
	10 mM	0.3770 mL	1.8849 mL	3.7697 mL	9.4244 mL
	15 mM	0.2513 mL	1.2566 mL	2.5132 mL	6.2829 mL
	20 mM	0.1885 mL	0.9424 mL	1.8849 mL	4.7122 mL
	25 mM	0.1508 mL	0.7539 mL	1.5079 mL	3.7697 mL
	30 mM	0.1257 mL	0.6283 mL	1.2566 mL	3.1415 mL
	40 mM	0.0942 mL	0.4712 mL	0.9424 mL	2.3561 mL
	50 mM	0.0754 mL	0.3770 mL	0.7539 mL	1.8849 mL
	60 mM	0.0628 mL	0.3141 mL	0.6283 mL	1.5707 mL
	80 mM	0.0471 mL	0.2356 mL	0.4712 mL	1.1780 mL
	100 mM	0.0377 mL	0.1885 mL	0.3770 mL	0.9424 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Galidesivir (Synonyms: BCX4430; Immucillin-A)

Customer Review

Other Forms of Galidesivir:

MCE 顾客使用本产品发表的 8 篇科研文献