Brivudine (Synonyms: 溴夫定; Bromovinyldeoxyuridine; BVDU)

目录号: HY-13578 纯度: 99.72%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

Brivudine是具有抗病毒活性的胸苷类似物,用于早期急性带状疱疹的研究。

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Brivudine Chemical Structure

CAS No. : 69304-47-8

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥385	In-stock
25 mg	￥350	In-stock
50 mg	￥490	In-stock
100 mg	￥630	In-stock
500 mg	￥1588	In-stock
1 g		询价
5 g		询价

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Other Forms of Brivudine:

Brivudine (Standard) 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•EMBO Mol Med. 2022 Nov 2;e16194. [Abstract]

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生物活性
纯度 & 产品资料
参考文献

生物活性

Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	EC₅₀	> 100 μM Compound: 6; BVDU; Brivudin	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 27032331]
BC-3	IC₅₀	> 15 μM Compound: BVDU	Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells after 120 hrs by MTT assay Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells after 120 hrs by MTT assay	[PMID: 17402726]
C3H	EC₅₀	> 100 μg/mL Compound: brivudin	Antiviral activity against MSV in mouse C3H cells assessed as inhibition of virus-induced transformation after 6 days Antiviral activity against MSV in mouse C3H cells assessed as inhibition of virus-induced transformation after 6 days	[PMID: 17298047]
CCRF-CEM	IC₅₀	> 100 μM Compound: BVdU	Cytostatic activity against human CD4-positive CEM cells after 3 days by cell counting method Cytostatic activity against human CD4-positive CEM cells after 3 days by cell counting method	[PMID: 27818111]
CCRF-CEM	EC₅₀	> 50 μM Compound: BVDU	Concentration required to inhibit human immunodeficiency virus-1 (strain ROD) induced cytopathogenicity in CEM cells by 50% Concentration required to inhibit human immunodeficiency virus-1 (strain ROD) induced cytopathogenicity in CEM cells by 50%	[PMID: 16000005]
CCRF-CEM	EC₅₀	> 50 μM Compound: BVDU	Concentration required to inhibit human immunodeficiency virus-1 (strain IIIb) induced cytopathogenicity in CEM cells by 50% Concentration required to inhibit human immunodeficiency virus-1 (strain IIIb) induced cytopathogenicity in CEM cells by 50%	[PMID: 16000005]
CCRF-CEM	IC₅₀	100 μM Compound: BVdU	Cytostatic activity against thymidine kinase deficient human CD4-positive CEM cells after 3 days by cell counting method Cytostatic activity against thymidine kinase deficient human CD4-positive CEM cells after 3 days by cell counting method	[PMID: 27818111]
CCRF-CEM	CC₅₀	207 μM Compound: 1f; BVdU	Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability incubated for 4 to 5 days Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability incubated for 4 to 5 days	[PMID: 32515595]
CCRF-HSB-2	IC₅₀	> 100 μg/mL Compound: 7	Compound was evaluated for the cytotoxicity against human T-cell leukemia, CCRF-HSB-2 by using MTT assay. Compound was evaluated for the cytotoxicity against human T-cell leukemia, CCRF-HSB-2 by using MTT assay.	[PMID: 10206544]
DG-75	IC₅₀	> 15 μM Compound: BVDU	Cytotoxicity against DG75 cells after 120 hrs by MTT assay Cytotoxicity against DG75 cells after 120 hrs by MTT assay	[PMID: 17402726]
E6SM	EC₅₀	> 400 μg/mL Compound: brivudin	Effective concentration required to reduce vaccinia virus plaque formation by 50% in E6SM Cell Culture Effective concentration required to reduce vaccinia virus plaque formation by 50% in E6SM Cell Culture	[PMID: 15481985]
E6SM	EC₅₀	0.01 μg/mL Compound: brivudin	Effective concentration required to reduce HSV-1 strain KOS virus plaque formation by 50% in E6SM Cell Culture Effective concentration required to reduce HSV-1 strain KOS virus plaque formation by 50% in E6SM Cell Culture	[PMID: 15481985]
E6SM	EC₅₀	16 μg/mL Compound: brivudin	Effective concentration required to reduce HSV-1 strain KOS ACV virus plaque formation by 50% in E6SM Cell Culture Effective concentration required to reduce HSV-1 strain KOS ACV virus plaque formation by 50% in E6SM Cell Culture	[PMID: 15481985]
E6SM	EC₅₀	80 μg/mL Compound: brivudin	Effective concentration required to reduce HSV-2 strain G virus plaque formation by 50% in E6SM Cell Culture Effective concentration required to reduce HSV-2 strain G virus plaque formation by 50% in E6SM Cell Culture	[PMID: 15481985]
HEL	IC₅₀	> 100 μg/mL Compound: BVDU	Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain AD-169 plaque formation by 50%. Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain AD-169 plaque formation by 50%.	[PMID: 7877148]
HEL	IC₅₀	> 100 μg/mL Compound: BVDU	Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain Davis plaque formation by 50%. Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain Davis plaque formation by 50%.	[PMID: 7877148]
HEL	CC₅₀	> 100 μM Compound: BVDU	Cytostatic against human HEL cells assessed as reduction in cell growth after 3 days by coulter counter Cytostatic against human HEL cells assessed as reduction in cell growth after 3 days by coulter counter	[PMID: 22578783]
HEL	EC₅₀	> 100 μM Compound: Brivudin	Antiviral activity against thymidine kinase-deficient VZV 07/1 infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 5 days Antiviral activity against thymidine kinase-deficient VZV 07/1 infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 5 days	[PMID: 21128666]
HEL	EC₅₀	> 100 μM Compound: BVDU	Concentration required to inhibit human cytomegalovirus strain AD169 induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit human cytomegalovirus strain AD169 induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	EC₅₀	> 100 μM Compound: BVDU	Concentration required to inhibit human cytomegalovirus strain Davis induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit human cytomegalovirus strain Davis induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	EC₅₀	> 100 μM Compound: Brivudin	Effective concentration required to inhibit human cytomegalo virus Davis induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection Effective concentration required to inhibit human cytomegalo virus Davis induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection	[PMID: 15801851]
HEL	EC₅₀	> 100 μM Compound: Brivudin	Effective concentration required to inhibit human cytomegalo virus AD-169 induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection Effective concentration required to inhibit human cytomegalo virus AD-169 induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection	[PMID: 15801851]
HEL	IC₅₀	> 100 μM Compound: BVDU	The compound was tested for cytotoxic concentration required to reduce human embryonic lung cell growth by 50% The compound was tested for cytotoxic concentration required to reduce human embryonic lung cell growth by 50%	[PMID: 10411487]
HEL	EC₅₀	> 108 μM Compound: BVDU	Concentration required to inhibit Varicella-Zoster virus (strain 07/1) induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit Varicella-Zoster virus (strain 07/1) induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	CC₅₀	> 150 μM Compound: BVDU	Cytotoxicity against HEL cells after 3 days Cytotoxicity against HEL cells after 3 days	[PMID: 17622128]
HEL	EC₅₀	> 150 μM Compound: brivudin	Effective concentration required to reduce CMV AD169 strain virus plaque formation by 50% in HEL cell culture Effective concentration required to reduce CMV AD169 strain virus plaque formation by 50% in HEL cell culture	[PMID: 15481985]
HEL	EC₅₀	> 150 μM Compound: 6 (BVDU)	Evaluated for the anti-VZV, the concentration of compounds in uM required to reduce VZVTK-07 ( thymidine kinase-deficient strain ) plaque formation after 5 days in HEL cell cultures compared to untreated controls. Evaluated for the anti-VZV, the concentration of compounds in uM required to reduce VZVTK-07 ( thymidine kinase-deficient strain ) plaque formation after 5 days in HEL cell cultures compared to untreated controls.	[PMID: 11150169]
HEL	EC₅₀	> 150 μM Compound: 6 (BVDU)	Evaluated for the anti-VZV, the concentration of compounds in uM required to reduce VZVTK-YS-R ( thymidine kinase-deficient strain ) plaque formation after 5 days in HEL cell cultures compared to untreated controls. Evaluated for the anti-VZV, the concentration of compounds in uM required to reduce VZVTK-YS-R ( thymidine kinase-deficient strain ) plaque formation after 5 days in HEL cell cultures compared to untreated controls.	[PMID: 11150169]
HEL	CC₅₀	> 200 μg/mL Compound: Brivudin	Cytotoxic concentration reducing HEL cell growth by 50%. Cytotoxic concentration reducing HEL cell growth by 50%.	[PMID: 12217359]
HEL	EC₅₀	> 200 μM Compound: 13, BVdU	Antiviral activity against TK- VZV 07 in HEL cells after 5 days Antiviral activity against TK- VZV 07 in HEL cells after 5 days	[PMID: 18052321]
HEL	EC₅₀	> 200 μM Compound: 13, BVdU	Antiviral activity against TK- VZV YS in HEL cells after 5 days Antiviral activity against TK- VZV YS in HEL cells after 5 days	[PMID: 18052321]
HEL	EC₅₀	> 250 μg/mL Compound: Brivudin	Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	[PMID: 20971531]
HEL	EC₅₀	> 250 μg/mL Compound: Brivudin	Antiviral activity against thymidine kinase deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay Antiviral activity against thymidine kinase deficient acyclovir-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	[PMID: 20971531]
HEL	EC₅₀	> 250 μg/mL Compound: Brivudine	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	[PMID: 20724039]
HEL	EC₅₀	> 250 μg/mL Compound: brivudin	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	[PMID: 19419804]
HEL	EC₅₀	> 250 μg/mL Compound: brivudin	Antiviral activity against thymidine kinase-deficient ACV-resistant HSV1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days Antiviral activity against thymidine kinase-deficient ACV-resistant HSV1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	[PMID: 19419804]
HEL	EC₅₀	> 250 μg/mL Compound: brivudin	Antiviral activity against VSV infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days Antiviral activity against VSV infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	[PMID: 18851889]
HEL	CC₅₀	> 250 μM Compound: BVDU	Cytotoxicity against HEL cells after 3 days by coulter counter analysis Cytotoxicity against HEL cells after 3 days by coulter counter analysis	[PMID: 21232828]
HEL	EC₅₀	> 250 μM Compound: Brivudine	Antiviral activity against VSV infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 1 to 2 days by MTT assay Antiviral activity against VSV infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 1 to 2 days by MTT assay	[PMID: 20034711]
HEL	EC₅₀	> 250 μM Compound: Brivudin	Antiviral activity against acyclovir-resistant TK-deficient Hepres simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay Antiviral activity against acyclovir-resistant TK-deficient Hepres simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay	10.1007/s00044-009-9248-y
HEL	EC₅₀	> 250 μM Compound: Brivudin	Antiviral activity against Vesicular stomatitis virus infected HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay Antiviral activity against Vesicular stomatitis virus infected HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay	10.1007/s00044-009-9248-y
HEL	EC₅₀	> 250 μM Compound: Brivudin	Antiviral activity against acyclovir-resistant thymidine kinase negative Human herpesvirus 1 strain KOS infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay Antiviral activity against acyclovir-resistant thymidine kinase negative Human herpesvirus 1 strain KOS infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	[PMID: 32214762]
HEL	EC₅₀	> 250 μM Compound: Brivudin	Antiviral activity against Vesicular stomatitis virus infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay Antiviral activity against Vesicular stomatitis virus infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	[PMID: 32214762]
HEL	CC₅₀	> 250 μM Compound: Brivudin	Cytotoxicity against human HEL cells after 3 days Cytotoxicity against human HEL cells after 3 days	[PMID: 21128666]
HEL	EC₅₀	> 250 μM Compound: Brivudin	Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	[PMID: 22459876]
HEL	EC₅₀	> 250 μM Compound: Brivudin	Antiviral activity against HCMV AD169/Davis infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days Antiviral activity against HCMV AD169/Davis infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	[PMID: 21128666]
HEL	CC₅₀	> 250 μM Compound: Brivudine	Cytotoxicity against Herpes simplex virus 1 KOS infected HEL cells by trypan blue exclusion method Cytotoxicity against Herpes simplex virus 1 KOS infected HEL cells by trypan blue exclusion method	[PMID: 20034711]
HEL	CC₅₀	> 250 μM Compound: Brivudine	Cytotoxicity against Herpes simplex virus 2 G infected HEL cells by trypan blue exclusion method Cytotoxicity against Herpes simplex virus 2 G infected HEL cells by trypan blue exclusion method	[PMID: 20034711]
HEL	CC₅₀	> 250 μM Compound: Brivudine	Cytotoxicity against Vaccinia virus infected HEL cells by trypan blue exclusion method Cytotoxicity against Vaccinia virus infected HEL cells by trypan blue exclusion method	[PMID: 20034711]
HEL	CC₅₀	> 250 μM Compound: Brivudine	Cytotoxicity against VSV infected HEL cells by trypan blue exclusion method Cytotoxicity against VSV infected HEL cells by trypan blue exclusion method	[PMID: 20034711]
HEL	CC₅₀	> 250 μM Compound: Brivudine	Cytotoxicity against acyclovir-sensitive Herpes simplex virus 1 KOS infected HEL cells by trypan blue exclusion method Cytotoxicity against acyclovir-sensitive Herpes simplex virus 1 KOS infected HEL cells by trypan blue exclusion method	[PMID: 20034711]
HEL	CC₅₀	> 300 μM Compound: Brivudine	Cytotoxicity against human HEL cells assessed as reduction in cell growth measured after 3 days by coulter counting method Cytotoxicity against human HEL cells assessed as reduction in cell growth measured after 3 days by coulter counting method	[PMID: 35754374]
HEL	CC₅₀	> 300 μM Compound: Brivudin	Cytotoxicity against human HEL cells assessed as reduce in cell growth incubated for 3 days by coulter counter analysis Cytotoxicity against human HEL cells assessed as reduce in cell growth incubated for 3 days by coulter counter analysis	[PMID: 33479570]
HEL	CC₅₀	> 300 μM Compound: Brivudin	Cytotoxicity against human HEL cells assessed as reduction in cell growth incubated for 3 days by coulter counter method Cytotoxicity against human HEL cells assessed as reduction in cell growth incubated for 3 days by coulter counter method	[PMID: 33039724]
HEL	CC₅₀	> 300 μM Compound: Brivudin	Cytotoxicity against human HEL cells assessed as reduction in cell proliferation incubated for 3 days by Coulter counter method Cytotoxicity against human HEL cells assessed as reduction in cell proliferation incubated for 3 days by Coulter counter method	[PMID: 32676147]
HEL	CC₅₀	> 300 μM Compound: Brivudine	Cytostatic activity against human HEL cells after 3 days by coulter counter method Cytostatic activity against human HEL cells after 3 days by coulter counter method	[PMID: 29945100]
HEL	CC₅₀	> 300 μM Compound: Brivudine	Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method	[PMID: 29670705]
HEL	CC₅₀	> 300 μM Compound: Brivudin	Cytostatic activity against HEL cells after 3 days by Coulter counting method Cytostatic activity against HEL cells after 3 days by Coulter counting method	[PMID: 29550734]
HEL	CC₅₀	> 300 μM Compound: Brivudine	Cytostatic activity against HEL cells after 3 days by Coulter counting method Cytostatic activity against HEL cells after 3 days by Coulter counting method	[PMID: 29407990]
HEL	CC₅₀	> 300 μM Compound: BVDU	Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method	[PMID: 29268134]
HEL	CC₅₀	> 300 μM Compound: Brivudine	Cytotoxic activity against HEL cells assessed as reduction in cell proliferation after 3 days by coulter counting method Cytotoxic activity against HEL cells assessed as reduction in cell proliferation after 3 days by coulter counting method	[PMID: 28682067]
HEL	CC₅₀	> 300 μM Compound: Brivudine	Cytotoxicity against human HEL cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method Cytotoxicity against human HEL cells assessed as reduction in cell viability measured after 3 days by beckman coulter counting method	[PMID: 33894564]
HEL	EC₅₀	> 400 μM Compound: brivudin	Effective concentration required to reduce CMV davis strain virus plaque formation by 50% in HEL cell culture Effective concentration required to reduce CMV davis strain virus plaque formation by 50% in HEL cell culture	[PMID: 15481985]
HEL	CC₅₀	> 400 μM Compound: 6 (BVDU)	cytostatic concentration required to reduce the HEL cell number by 50%. after 5 days in the absence of virus cytostatic concentration required to reduce the HEL cell number by 50%. after 5 days in the absence of virus	[PMID: 11150169]
HEL	CC₅₀	> 50 μg/mL Compound: BVDU	Tested for the cytotoxic concentration, required to reduce cell growth by 50% in human embryonic lung (HEL) cells. Tested for the cytotoxic concentration, required to reduce cell growth by 50% in human embryonic lung (HEL) cells.	[PMID: 7877148]
HEL	IC₅₀	> 50 μM Compound: BVDU	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK-(deficient) 07/1 strain The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK-(deficient) 07/1 strain	[PMID: 10411487]
HEL	IC₅₀	> 50 μM Compound: BVDU	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK-(deficient) YS/R strain The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK-(deficient) YS/R strain	[PMID: 10411487]
HEL	EC₅₀	> 500 μM Compound: BVDU	Concentration required to inhibit vesicular stomatitis virus induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit vesicular stomatitis virus induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	EC₅₀	≥ 120 μM Compound: Brivudin	Antiviral activity against thymidine kinase negative VZV YS/R infected in HEL cells by plaque formation assay Antiviral activity against thymidine kinase negative VZV YS/R infected in HEL cells by plaque formation assay	[PMID: 22858222]
HEL	EC₅₀	≥ 130 μM Compound: BVDU	Antiviral activity against thymidine kinase deficient VZV YS/R in HEL cells assessed as reduction of virus plaque formation after 5 days Antiviral activity against thymidine kinase deficient VZV YS/R in HEL cells assessed as reduction of virus plaque formation after 5 days	[PMID: 17622128]
HEL	EC₅₀	≥ 183 μM Compound: Brivudin	Antiviral activity against thymidine kinase negative and ACV resistant HSV1 KOS infected in HEL cells by viral CPE assay Antiviral activity against thymidine kinase negative and ACV resistant HSV1 KOS infected in HEL cells by viral CPE assay	[PMID: 22858222]
HEL	CC₅₀	≥ 400 μM Compound: BVDU	Concentration required to inhibit cell proliferation in HEL cells by 50% Concentration required to inhibit cell proliferation in HEL cells by 50%	[PMID: 16000005]
HEL	CC₅₀	≥ 79.3 μM Compound: Brivudin	Cytotoxicity against Varicella zoster virus infected HEL cells assessed as cell growth inhibition incubated for 3 days by coulter counter method Cytotoxicity against Varicella zoster virus infected HEL cells assessed as cell growth inhibition incubated for 3 days by coulter counter method	[PMID: 26443550]
HEL	EC₅₀	≥ 99 μM Compound: BVDU	Antiviral activity against thymidine kinase deficient VZV 07/1 in HEL cells assessed as reduction of virus plaque formation after 5 days Antiviral activity against thymidine kinase deficient VZV 07/1 in HEL cells assessed as reduction of virus plaque formation after 5 days	[PMID: 17622128]
HEL	IC₅₀	0.0007 μg/mL Compound: BVDU	Tested for the inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain OKA plaque formation by 50%. Tested for the inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain OKA plaque formation by 50%.	[PMID: 7877148]
HEL	IC₅₀	0.001 μM Compound: BVDU	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK+OKA strain The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK+OKA strain	[PMID: 10411487]
HEL	IC₅₀	0.0015 μg/mL Compound: BVDU	Tested for the inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain YS plaque formation by 50% Tested for the inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain YS plaque formation by 50%	[PMID: 7877148]
HEL	EC₅₀	0.003 μM Compound: brivudin	Effective concentration required to reduce TK+ (thymidine kinase presence) VZV strain YS virus plaque formation by 50% in HEL cell culture Effective concentration required to reduce TK+ (thymidine kinase presence) VZV strain YS virus plaque formation by 50% in HEL cell culture	[PMID: 15481985]
HEL	EC₅₀	0.003 μM Compound: brivudin	Effective concentration required to reduce TK+ (thymidine kinase presence) VZV strain OKA virus plaque formation by 50% in HEL cell culture Effective concentration required to reduce TK+ (thymidine kinase presence) VZV strain OKA virus plaque formation by 50% in HEL cell culture	[PMID: 15481985]
HEL	EC₅₀	0.003 μM Compound: 6 (BVDU)	Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV OKA Plaque formation after 5 days in HEL cell cultures compared to untreated controls. Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV OKA Plaque formation after 5 days in HEL cell cultures compared to untreated controls.	[PMID: 11150169]
HEL	EC₅₀	0.003 μM Compound: 6 (BVDU)	Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV TS plaque formation after 5 days in HEL cell cultures compared to untreated controls. Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV TS plaque formation after 5 days in HEL cell cultures compared to untreated controls.	[PMID: 11150169]
HEL	EC₅₀	0.005 μM Compound: 13, BVdU	Antiviral activity against TK+ VZV OKA in HEL cells after 5 days Antiviral activity against TK+ VZV OKA in HEL cells after 5 days	[PMID: 18052321]
HEL	EC₅₀	0.005 μM Compound: 13, BVdU	Antiviral activity against TK+ VZV YS in HEL cells after 5 days Antiviral activity against TK+ VZV YS in HEL cells after 5 days	[PMID: 18052321]
HEL	IC₅₀	0.005 μM Compound: BVDU	The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK+YS strain The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK+YS strain	[PMID: 10411487]
HEL	EC₅₀	0.006 μM Compound: Brivudin	Antiviral activity against thymidine kinase positive VZV YS infected in HEL cells by plaque formation assay Antiviral activity against thymidine kinase positive VZV YS infected in HEL cells by plaque formation assay	[PMID: 22858222]
HEL	EC₅₀	0.01 μM Compound: Brivudine	Antiviral activity against VZV OKA expressing thymidine kinase infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 3 days Antiviral activity against VZV OKA expressing thymidine kinase infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 3 days	[PMID: 23047229]
HEL	EC₅₀	0.01 μM Compound: Brivudin	Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	[PMID: 22459876]
HEL	EC₅₀	0.01 μM Compound: BVDU	Antiviral activity against TK+ VZV YS in HEL cells assessed as reduction of virus plaque formation after 5 days Antiviral activity against TK+ VZV YS in HEL cells assessed as reduction of virus plaque formation after 5 days	[PMID: 17622128]
HEL	EC₅₀	0.01 μM Compound: BVDU	Antiviral activity against TK+ VZV OKA in HEL cells assessed as reduction of virus plaque formation after 5 days Antiviral activity against TK+ VZV OKA in HEL cells assessed as reduction of virus plaque formation after 5 days	[PMID: 17622128]
HEL	EC₅₀	0.01 μM Compound: Brivudin	Antiviral activity against thymidine kinase positive VZV OKa infected in HEL cells by plaque formation assay Antiviral activity against thymidine kinase positive VZV OKa infected in HEL cells by plaque formation assay	[PMID: 22858222]
HEL	EC₅₀	0.012 μM Compound: Brivudin	Antiviral activity against VZV OKA expressing thymidine kinase infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 5 days Antiviral activity against VZV OKA expressing thymidine kinase infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 5 days	[PMID: 21128666]
HEL	EC₅₀	0.014 μM Compound: brivudin	Antiviral activity against thymidine kinase-positive VZV OKA in human HEL cells after 7 days Antiviral activity against thymidine kinase-positive VZV OKA in human HEL cells after 7 days	[PMID: 17672445]
HEL	EC₅₀	0.015 μM Compound: brivudin	Antiviral activity against Varicella zoster virus OKA infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days Antiviral activity against Varicella zoster virus OKA infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days	[PMID: 19339082]
HEL	EC₅₀	0.019 μM Compound: Brivudin	Antiviral activity against VSV OKA expressing thymidine kinase infected in HEL cells assessed as reduction of virus plaque formation after 4 days Antiviral activity against VSV OKA expressing thymidine kinase infected in HEL cells assessed as reduction of virus plaque formation after 4 days	[PMID: 22459876]
HEL	EC₅₀	0.026 μM Compound: brivudin	Antiviral activity against Varicella zoster virus YS infected in human HEL cells assessed as inhibition of virus induced cytopathicity after 5 days Antiviral activity against Varicella zoster virus YS infected in human HEL cells assessed as inhibition of virus induced cytopathicity after 5 days	[PMID: 19339082]
HEL	EC₅₀	0.03 μM Compound: BVDU	Concentration required to inhibit Varicella-Zoster virus (strain OKA) induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit Varicella-Zoster virus (strain OKA) induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	EC₅₀	0.03 μM Compound: Brivudin	Effective concentration required to reduce Varicella-Zoster virus OKA(TK) plaque formation after 5 days in HEL fibroblast cell line Effective concentration required to reduce Varicella-Zoster virus OKA(TK) plaque formation after 5 days in HEL fibroblast cell line	[PMID: 15801851]
HEL	EC₅₀	0.038 μM Compound: Brivudin	Antiviral activity against HSV1 KOS infected in HEL cells by viral CPE assay Antiviral activity against HSV1 KOS infected in HEL cells by viral CPE assay	[PMID: 22858222]
HEL	EC₅₀	0.04 μg/mL Compound: Brivudine	Antiviral activity against Herpes simplex virus-1 KOS infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days Antiviral activity against Herpes simplex virus-1 KOS infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	[PMID: 20724039]
HEL	EC₅₀	0.04 μg/mL Compound: brivudin	Antiviral activity against HSV1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days Antiviral activity against HSV1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	[PMID: 18851889]
HEL	EC₅₀	0.04 μM Compound: Brivudin	Antiviral activity against HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days Antiviral activity against HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	[PMID: 21128666]
HEL	EC₅₀	0.08 μg/mL Compound: Brivudin	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	[PMID: 20971531]
HEL	EC₅₀	0.08 μg/mL Compound: brivudin	Antiviral activity against HSV1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days Antiviral activity against HSV1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	[PMID: 19419804]
HEL	EC₅₀	0.08 μM Compound: Brivudine	Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	[PMID: 20034711]
HEL	EC₅₀	0.08 μM Compound: Brivudin	Antiviral activity against Human herpesvirus 1 strain KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay Antiviral activity against Human herpesvirus 1 strain KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay	10.1007/s00044-009-9248-y
HEL	EC₅₀	0.08 μM Compound: Brivudin	Antiviral activity against Human herpesvirus 1 strain KOS infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay Antiviral activity against Human herpesvirus 1 strain KOS infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	[PMID: 32214762]
HEL	EC₅₀	0.08 μM Compound: Brivudin	Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	[PMID: 21696963]
HEL	EC₅₀	0.089 μM Compound: Brivudin	Antiviral activity against thymidine kinase positive Varicella zoster virus OKA infected in human HEL cells assessed as reduction in plaque formation measured after 5 days Antiviral activity against thymidine kinase positive Varicella zoster virus OKA infected in human HEL cells assessed as reduction in plaque formation measured after 5 days	[PMID: 32676147]
HEL	EC₅₀	0.16 μM Compound: BVDU	Concentration required to inhibit herpes simplex virus type 1 induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit herpes simplex virus type 1 induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	EC₅₀	0.18 μM Compound: Brivudin	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07-1 infected in human HEL cells assessed as reduction in plaque formation measured after 5 days Antiviral activity against thymidine kinase deficient Varicella zoster virus 07-1 infected in human HEL cells assessed as reduction in plaque formation measured after 5 days	[PMID: 32676147]
HEL	EC₅₀	1.5 μM Compound: Brivudin	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	[PMID: 21128666]
HEL	EC₅₀	10 μg/mL Compound: brivudin	Antiviral activity against Vaccinia virus infected in in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days Antiviral activity against Vaccinia virus infected in in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	[PMID: 19419804]
HEL	EC₅₀	10 μM Compound: Brivudin	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay	10.1007/s00044-009-9248-y
HEL	EC₅₀	10 μM Compound: Brivudin	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	[PMID: 22459876]
HEL	EC₅₀	10 μM Compound: Brivudin	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis Antiviral activity against Vaccinia virus infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	[PMID: 21696963]
HEL	EC₅₀	103 μM Compound: Brivudin	Effective concentration required to reduce Varicella-Zoster virus 07/1(TK-) plaque formation after 5 days in HEL fibroblast cell line Effective concentration required to reduce Varicella-Zoster virus 07/1(TK-) plaque formation after 5 days in HEL fibroblast cell line	[PMID: 15801851]
HEL	EC₅₀	105 μM Compound: Brivudin	Antiviral activity against HSV2 G infected in HEL cells by viral CPE assay Antiviral activity against HSV2 G infected in HEL cells by viral CPE assay	[PMID: 22858222]
HEL	EC₅₀	112 μg/mL Compound: Brivudin	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	[PMID: 20971531]
HEL	EC₅₀	117 μM Compound: Brivudine	Antiviral activity against thymidine kinase-deficient VZV 07/1 infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days Antiviral activity against thymidine kinase-deficient VZV 07/1 infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days	[PMID: 23047229]
HEL	CC₅₀	122 μg/mL Compound: brivudin	Cytotoxicity against HEL cells assessed as reduction of growth after 3 days Cytotoxicity against HEL cells assessed as reduction of growth after 3 days	[PMID: 18835175]
HEL	EC₅₀	126 μg/mL Compound: brivudin	Antiviral activity against HSV2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days Antiviral activity against HSV2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 3 days	[PMID: 19419804]
HEL	EC₅₀	126 μM Compound: Brivudin	Antiviral activity against Human herpesvirus 2 strain G infected HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay Antiviral activity against Human herpesvirus 2 strain G infected HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTT assay	10.1007/s00044-009-9248-y
HEL	EC₅₀	15 μM Compound: Brivudin	Antiviral activity against Vaccinia virus Lederie infected in HEL cells by viral CPE assay Antiviral activity against Vaccinia virus Lederie infected in HEL cells by viral CPE assay	[PMID: 22858222]
HEL	CC₅₀	150 μg/mL Compound: BVDU	Cytotoxic concentration required to reduce cell growth HEL cells (after 3 days) by 50 % Cytotoxic concentration required to reduce cell growth HEL cells (after 3 days) by 50 %	10.1016/0960-894X(95)00278-2
HEL	EC₅₀	150 μM Compound: Brivudin	Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	[PMID: 32214762]
HEL	EC₅₀	157 μM Compound: brivudin	Antiviral activity against thymidine kinase deficient Varicella zoster virus 07/1 infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days Antiviral activity against thymidine kinase deficient Varicella zoster virus 07/1 infected in human HEL cells assessed as inhibition of virus-induced cytopathicity after 5 days	[PMID: 19339082]
HEL	CC₅₀	160 μM Compound: Brivudin	Cytotoxicity against HEL cells assessed as growth inhibition after 3 days by coulter counter method Cytotoxicity against HEL cells assessed as growth inhibition after 3 days by coulter counter method	[PMID: 27639368]
HEL	EC₅₀	168 μM Compound: brivudin	Antiviral activity against thymidine kinase deficient VZV 07/1 in human HEL cells after 7 days Antiviral activity against thymidine kinase deficient VZV 07/1 in human HEL cells after 7 days	[PMID: 17672445]
HEL	EC₅₀	2 μM Compound: Brivudine	Antiviral activity against Vaccinia virus infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay Antiviral activity against Vaccinia virus infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	[PMID: 20034711]
HEL	CC₅₀	212 μg/mL Compound: brivudin	Cytotoxicity against HEL cells assessed as cell growth after 3 days Cytotoxicity against HEL cells assessed as cell growth after 3 days	[PMID: 17948980]
HEL	CC₅₀	242 μM Compound: Brivudine	Cytotoxicity against HEL cells assessed as reduction in cell growth after 3 days by coulter counter method Cytotoxicity against HEL cells assessed as reduction in cell growth after 3 days by coulter counter method	[PMID: 28757102]
HEL	EC₅₀	250 μg/mL Compound: Brivudin	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	[PMID: 20971531]
HEL	EC₅₀	250 μg/mL Compound: Brivudine	Antiviral activity against acyclovir-resistant TK deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days Antiviral activity against acyclovir-resistant TK deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	[PMID: 20724039]
HEL	EC₅₀	250 μM Compound: Brivudin	Antiviral activity against thymidine kinase-deficient acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days Antiviral activity against thymidine kinase-deficient acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	[PMID: 22459876]
HEL	EC₅₀	250 μM Compound: Brivudin	Antiviral activity against acyclovir-resistant TK-deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis Antiviral activity against acyclovir-resistant TK-deficient Herpes simplex virus-1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	[PMID: 21696963]
HEL	EC₅₀	250 μM Compound: Brivudin	Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 4 days by microscopic analysis	[PMID: 21696963]
HEL	EC₅₀	250 μM Compound: Brivudin	Antiviral activity against acyclovir-resistant thymidine kinase deficient HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days Antiviral activity against acyclovir-resistant thymidine kinase deficient HSV1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	[PMID: 21128666]
HEL	EC₅₀	29 μg/mL Compound: brivudin	Antiviral activity against HSV2 G infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days Antiviral activity against HSV2 G infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	[PMID: 18851889]
HEL	EC₅₀	29 μM Compound: Brivudin	Antiviral activity against Vaccinia virus infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay Antiviral activity against Vaccinia virus infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	[PMID: 32214762]
HEL	EC₅₀	29 μM Compound: brivudin	Effective concentration required to reduce TK+ (thymidine kinase deficient) VZV strain 07/1 virus plaque formation by 50% in HEL cell culture Effective concentration required to reduce TK+ (thymidine kinase deficient) VZV strain 07/1 virus plaque formation by 50% in HEL cell culture	[PMID: 15481985]
HEL	IC₅₀	30 μg/mL Compound: BVDU	Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain YS/R plaque formation by 50%. Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain YS/R plaque formation by 50%.	[PMID: 7877148]
HEL	EC₅₀	30 μM Compound: Brivudin	Antiviral activity against HSV2 G infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days Antiviral activity against HSV2 G infected in human HEL cells assessed as reduction of virus-induced cytopathogenicity after 7 days	[PMID: 21128666]
HEL	EC₅₀	300 μM Compound: BVDU	Concentration required to inhibit herpes simplex virus type 2 induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit herpes simplex virus type 2 induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	CC₅₀	339 μM Compound: Brivudine	Cytotoxicity against HEL after 3 days Cytotoxicity against HEL after 3 days	[PMID: 23047229]
HEL	CC₅₀	347 μM Compound: Brivudin	Cytotoxicity against HEL cells assessed as effect on cell growth incubated for 3 days by Coulter counter assay Cytotoxicity against HEL cells assessed as effect on cell growth incubated for 3 days by Coulter counter assay	[PMID: 22858222]
HEL	EC₅₀	4 μg/mL Compound: Brivudine	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days Antiviral activity against Vaccinia virus infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	[PMID: 20724039]
HEL	CC₅₀	408 μM Compound: brivudin	Cytotoxicity against HEL cells assessed as cell growth after 7 days Cytotoxicity against HEL cells assessed as cell growth after 7 days	[PMID: 17539622]
HEL	CC₅₀	432 μM Compound: brivudin	Cytotoxicity against human HEL cells assessed as reduction in cell growth after 3 days Cytotoxicity against human HEL cells assessed as reduction in cell growth after 3 days	[PMID: 19339082]
HEL	CC₅₀	470 μM Compound: Brivudin	Cytotoxicity against human HEL cells assessed as growth inhibition after 3 days by coulter counter Cytotoxicity against human HEL cells assessed as growth inhibition after 3 days by coulter counter	[PMID: 21565516]
HEL	EC₅₀	5 μg/mL Compound: brivudin	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days Antiviral activity against Vaccinia virus infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	[PMID: 18851889]
HEL	EC₅₀	50 μg/mL Compound: Brivudine	Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days Antiviral activity against Herpes simplex virus-2 G infected in human HEL cells assessed as protection against virus-induced cytopathogenicity after 2 days	[PMID: 20724039]
HEL	EC₅₀	50 μM Compound: Brivudine	Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	[PMID: 20034711]
HEL	EC₅₀	50 μM Compound: Brivudine	Antiviral activity against acyclovir-sensitive Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay Antiviral activity against acyclovir-sensitive Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	[PMID: 20034711]
HEL	EC₅₀	50 μM Compound: Brivudin	Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days Antiviral activity against HSV2 G infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	[PMID: 22459876]
HEL	CC₅₀	512 μM Compound: Brivudin	Cytotoxicity against human HEL cells by colorimetric formazan-based MTS assay Cytotoxicity against human HEL cells by colorimetric formazan-based MTS assay	[PMID: 21696963]
HEL	EC₅₀	53 μM Compound: Brivudin	Antiviral activity against thymidine kinase negative VZV 07/01 infected in HEL cells by plaque formation assay Antiviral activity against thymidine kinase negative VZV 07/01 infected in HEL cells by plaque formation assay	[PMID: 22858222]
HEL	EC₅₀	56 μM Compound: brivudin	Effective concentration required to reduce TK+ (thymidine kinase deficient) VZV strain YS/R virus plaque formation by 50% in HEL cell culture Effective concentration required to reduce TK+ (thymidine kinase deficient) VZV strain YS/R virus plaque formation by 50% in HEL cell culture	[PMID: 15481985]
HEL	EC₅₀	60 μM Compound: BVDU	Concentration required to inhibit vaccinia virus induced cytopathogenicity in HEL cells by 50% Concentration required to inhibit vaccinia virus induced cytopathogenicity in HEL cells by 50%	[PMID: 16000005]
HEL	CC₅₀	600 μM Compound: brivudin	Cytotoxicity against human HEL cells assessed as reduction of growth after 3 days Cytotoxicity against human HEL cells assessed as reduction of growth after 3 days	[PMID: 19226140]
HEL	IC₅₀	8 μg/mL Compound: BVDU	Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain 07/1 plaque formation by 50%. Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain 07/1 plaque formation by 50%.	[PMID: 7877148]
HEL	EC₅₀	96 μg/mL Compound: brivudin	Antiviral activity against thymidine kinase-deficient acyclovir-resistant HSV1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days Antiviral activity against thymidine kinase-deficient acyclovir-resistant HSV1 KOS infected in human HEL cells assessed as reduction in virus-induced cytopathogenicity after 3 days	[PMID: 18851889]
HEL 299	CC₅₀	> 100 μM Compound: BVDU	Cytotoxicity against human HEL 299 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay Cytotoxicity against human HEL 299 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay	[PMID: 37252100]
HeLa	EC₅₀	> 250 μM Compound: brivudin	Antiviral activity against coxsackie B4 virus in HeLa cells assessed as reduction of virus plaque formation after 7 days Antiviral activity against coxsackie B4 virus in HeLa cells assessed as reduction of virus plaque formation after 7 days	[PMID: 17539622]
HeLa	IC₅₀	0.2 μM Compound: BVdU	Cytostatic activity against thymidine kinase deficient human HeLa cells after 3 days by cell counting method Cytostatic activity against thymidine kinase deficient human HeLa cells after 3 days by cell counting method	[PMID: 27818111]
HeLa	IC₅₀	160 μM Compound: BVdU	Cytostatic activity against human HeLa cells after 3 days by cell counting method Cytostatic activity against human HeLa cells after 3 days by cell counting method	[PMID: 27818111]
HeLa	CC₅₀	362 μM Compound: Brivudin	Cytotoxicity against human HeLa cells assessed as cell viability by colorimetric formazan-based MTS assay Cytotoxicity against human HeLa cells assessed as cell viability by colorimetric formazan-based MTS assay	[PMID: 22459876]
Jurkat	EC₅₀	> 100 μM Compound: 6; BVDU; Brivudin	Cytotoxicity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 27032331]
L1210	IC₅₀	38 μM Compound: BVdU	Cytostatic activity against mouse L1210 cells after 2 days by cell counting method Cytostatic activity against mouse L1210 cells after 2 days by cell counting method	[PMID: 27818111]
L1210	IC₅₀	9.6 μM Compound: BVdU	Cytostatic activity against thymidine kinase deficient mouse L1210 cells after 2 days by cell counting method Cytostatic activity against thymidine kinase deficient mouse L1210 cells after 2 days by cell counting method	[PMID: 27818111]
PC-3	EC₅₀	> 100 μM Compound: 6; BVDU; Brivudin	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 27032331]
Ramos	EC₅₀	> 100 μM Compound: 6; BVDU; Brivudin	Cytotoxicity against human Ramos cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human Ramos cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 27032331]
U-87MG ATCC	EC₅₀	> 100 μM Compound: 6; BVDU; Brivudin	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 27032331]
Vero	EC₅₀	> 150 μM Compound: BVDU	Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell in monolayers of HSV-2 AD Vero cells by 50% Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell in monolayers of HSV-2 AD Vero cells by 50%	[PMID: 11585457]
Vero	EC₅₀	> 150 μM Compound: BVDU	Inhibition of plaque formation in monolayers of HSV-1 KOSSB(TK-) Vero cells by 50% Inhibition of plaque formation in monolayers of HSV-1 KOSSB(TK-) Vero cells by 50%	[PMID: 11585457]
Vero	EC₅₀	> 200 μg/mL Compound: brivudin	Antiviral activity against Parainfluenza 3 in Vero cells reduction of virus-induced cytopathogenicity after 4 days Antiviral activity against Parainfluenza 3 in Vero cells reduction of virus-induced cytopathogenicity after 4 days	[PMID: 17948980]
Vero	EC₅₀	> 200 μg/mL Compound: brivudin	Antiviral activity against Reovirus 1 in Vero cells reduction of virus-induced cytopathogenicity after 4 days Antiviral activity against Reovirus 1 in Vero cells reduction of virus-induced cytopathogenicity after 4 days	[PMID: 17948980]
Vero	EC₅₀	> 200 μg/mL Compound: brivudin	Antiviral activity against Sindbis virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days Antiviral activity against Sindbis virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days	[PMID: 17948980]
Vero	EC₅₀	> 200 μg/mL Compound: brivudin	Antiviral activity against Punta Toro virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days Antiviral activity against Punta Toro virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days	[PMID: 17948980]
Vero	EC₅₀	> 250 μM Compound: brivudin	Antiviral activity against parainfluenza 3 virus in Vero cells assessed as reduction of virus plaque formation after 7 days Antiviral activity against parainfluenza 3 virus in Vero cells assessed as reduction of virus plaque formation after 7 days	[PMID: 17539622]
Vero	EC₅₀	> 250 μM Compound: brivudin	Antiviral activity against reovirus1 virus in Vero cells assessed as reduction of virus plaque formation after 7 days Antiviral activity against reovirus1 virus in Vero cells assessed as reduction of virus plaque formation after 7 days	[PMID: 17539622]
Vero	EC₅₀	> 250 μM Compound: brivudin	Antiviral activity against sindbis virus in Vero cells assessed as reduction of virus plaque formation after 7 days Antiviral activity against sindbis virus in Vero cells assessed as reduction of virus plaque formation after 7 days	[PMID: 17539622]
Vero	EC₅₀	> 250 μM Compound: brivudin	Antiviral activity against Punta Toro virus in Vero cells assessed as reduction of virus plaque formation after 7 days Antiviral activity against Punta Toro virus in Vero cells assessed as reduction of virus plaque formation after 7 days	[PMID: 17539622]
Vero	EC₅₀	> 300 μM Compound: BVdU	Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	[PMID: 17438061]
Vero	EC₅₀	> 300 μM Compound: BVdU	Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	[PMID: 17438061]
Vero	CC₅₀	> 600 μM Compound: BVdU	Cytotoxicity against african green monkey Vero cells after 2 days Cytotoxicity against african green monkey Vero cells after 2 days	[PMID: 17438061]
Vero	EC₅₀	0.003 μM Compound: BVDU	Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell in monolayers of VZV Ellen Vero cells by 50% Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell in monolayers of VZV Ellen Vero cells by 50%	[PMID: 11585457]
Vero	ED₅₀	0.07 μM Compound: BrVdu	In vitro antiviral activity was determined by plaque-reduction assay in HSV-1(strain 2931) infected Vero cell monolayers In vitro antiviral activity was determined by plaque-reduction assay in HSV-1(strain 2931) infected Vero cell monolayers	[PMID: 6317862]
Vero	EC₅₀	0.12 μM Compound: BVdU	Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	[PMID: 17438061]
Vero	EC₅₀	1.5 μM Compound: BVDU	Inhibition of plaque formation in monolayers of HSV-1 KOS Vero cells by 50% Inhibition of plaque formation in monolayers of HSV-1 KOS Vero cells by 50%	[PMID: 11585457]
Vero	ED₅₀	12.95 μM Compound: BrVdu	In vitro antiviral activity was determined by plaque-reduction assay in HSV-2 (strain G) infected Vero cell monolayers In vitro antiviral activity was determined by plaque-reduction assay in HSV-2 (strain G) infected Vero cell monolayers	[PMID: 6317862]
Vero	EC₅₀	2.7 μM Compound: BVDU	Inhibition of plaque formation in monolayers of HSV-1 E-377 Vero cells by 50% Inhibition of plaque formation in monolayers of HSV-1 E-377 Vero cells by 50%	[PMID: 11585457]

体外研究
(In Vitro)

Brivudine 是胸苷的类似物，并被掺入病毒 DNA 中。它阻断 DNA 聚合酶的作用，从而抑制病毒复制。与阿昔洛韦或喷昔洛韦等参比化合物相比，它对水痘-带状疱疹病毒具有更强的抗病毒作用^[1]。它对水痘带状疱疹病毒 (VZV) 具有高选择性活性，抑制 VZV 复制，可能通过竞争性抑制病毒 DNA 聚合酶，或作为脱氧胸苷三磷酸的替代底物，导致病毒 DNA 链断裂^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

在 125 毫克每天一次的剂量下，Brivudine 在减少新水疱产生的时间方面优于阿昔洛韦，并缩短了带状疱疹后神经痛的持续时间^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

333.14

Formula

C₁₁H₁₃BrN₂O₅

CAS 号

69304-47-8

性状

固体

颜色

White to off-white

中文名称

溴比夫定；溴夫定

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

溶解性数据

细胞实验：

DMSO 中的溶解度 : 200 mg/mL (600.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0017 mL	15.0087 mL	30.0174 mL
5 mM	0.6003 mL	3.0017 mL	6.0035 mL
10 mM	0.3002 mL	1.5009 mL	3.0017 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 10 mg/mL (30.02 mM); 澄清溶液

此方案可获得 ≥ 10 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 100.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 10 mg/mL (30.02 mM); 澄清溶液

此方案可获得 ≥ 10 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 100.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 10 mg/mL (30.02 mM); 澄清溶液

此方案可获得 ≥ 10 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 100.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.72%

选择批次：

Data Sheet (640 KB) SDS (393 KB)

COA (286 KB) HNMR (264 KB) LCMS (91 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. [Content Brief]

[2]. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9. [Content Brief]

Brivudine 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0017 mL	15.0087 mL	30.0174 mL	75.0435 mL
	5 mM	0.6003 mL	3.0017 mL	6.0035 mL	15.0087 mL
	10 mM	0.3002 mL	1.5009 mL	3.0017 mL	7.5044 mL
	15 mM	0.2001 mL	1.0006 mL	2.0012 mL	5.0029 mL
	20 mM	0.1501 mL	0.7504 mL	1.5009 mL	3.7522 mL
	25 mM	0.1201 mL	0.6003 mL	1.2007 mL	3.0017 mL
	30 mM	0.1001 mL	0.5003 mL	1.0006 mL	2.5015 mL
	40 mM	0.0750 mL	0.3752 mL	0.7504 mL	1.8761 mL
	50 mM	0.0600 mL	0.3002 mL	0.6003 mL	1.5009 mL
	60 mM	0.0500 mL	0.2501 mL	0.5003 mL	1.2507 mL
	80 mM	0.0375 mL	0.1876 mL	0.3752 mL	0.9380 mL
	100 mM	0.0300 mL	0.1501 mL	0.3002 mL	0.7504 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brivudine69304-47-8Bromovinyldeoxyuridine BVDU溴比夫定溴夫定CMVCytomegalovirusInhibitorinhibitorinhibit

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Brivudine (Synonyms: 溴夫定; Bromovinyldeoxyuridine; BVDU)

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Brivudine (Synonyms: 溴夫定; Bromovinyldeoxyuridine; BVDU)

Customer Review

Other Forms of Brivudine:

Brivudine 相关抗体

MCE 顾客使用本产品发表的 1 篇科研文献

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