Cantharidin (Synonyms: 斑蝥素; 班蝥酸酐; 斑蝥酸酐)

目录号: HY-N0209 纯度: 99.54%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

斑蝥素 (Cantharidin) 是从芫菁科和拟天牛科中分离到的天然毒素，对害虫具有毒害作用。

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Cantharidin Chemical Structure

CAS No. : 56-25-7

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规格	价格	是否有货
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50 mg	￥800	In-stock
100 mg	￥1050	In-stock
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Customer Review

MCE 顾客使用本产品发表的 4 篇科研文献

: Cantharidin purchased from MCE. Usage Cited in: Oncol Lett. 2018 May;15(5):6527-6532. [Abstract]; Cantharidin (CTD) enhances A549 cells autophagy. Western blotting of autophagy associated proteins LC3 I , LC3 II, Beclin 1 and p62 are analyzed.

: Cantharidin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2017 Aug 15;138:49-60. [Abstract]; Blockade of AMPK signals by AMPK α2 siRNA or AMPK inhibitor (Dorsomorphin; 2.5 μM, pretreatment 2 hours) treatment counteracts the apoptotic effects of Cantharidin at 2.5 μM. Data are representative of at least two independent experiments. Blocking AMPK signaling by knockdown of AMPK or Dorsomorphin (AMPK kinase inhibitor) treatment markedly reverses the apoptotic effect of Cantharidin, indicating that AMPK activation is required for the anti-HCC activity of Cantharidin.

: Cantharidin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2017 Aug 15;138:49-60. [Abstract]; Dose-dependent effects of Cantharidin on AMPK-related signaling in three HCC cell lines. The phosphorylation of AMPK is markedly upregulated, and so is its downstream effector phospho-ULK1, whereas PP5 expression is not affected after Cantharidin treatment.

: Cantharidin purchased from MCE. Usage Cited in: Lung Cancer. 2017 Oct;112:81-89. [Abstract]; Dose-and time-dependent effects of Cantharidin on p-AMPK, PARP, and Caspase 9. Cells are treated with Cantharidin at indicated concentrations for 24 hours or 2.5 μM Cantharidin for different time durations. The protein levels are analyzed with indicated antibodies.

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生物活性
纯度 & 产品资料
参考文献

生物活性

Cantharidin, a natural toxin isolated from beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
143B	GI₅₀	10 μM Compound: cantharidin	Inhibition of growth after 72 hr continuous exposure to test compounds in Osteosarcoma 143B tumor cell lines Inhibition of growth after 72 hr continuous exposure to test compounds in Osteosarcoma 143B tumor cell lines	[PMID: 11881984]
143B	IC₅₀	10 μM Compound: 1	Inhibitory activity against tumor osteosarcoma cell line 143B after 72 hr continuous exposure to compound Inhibitory activity against tumor osteosarcoma cell line 143B after 72 hr continuous exposure to compound	[PMID: 10937725]
A2780	GI₅₀	10 μM Compound: cantharidin	Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian A2780 tumor cell lines Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian A2780 tumor cell lines	[PMID: 11881984]
A2780	IC₅₀	10 μM Compound: 1	Inhibitory activity against ovarian tumor cell line A2780 after 72 hr continuous exposure to compound Inhibitory activity against ovarian tumor cell line A2780 after 72 hr continuous exposure to compound	[PMID: 10937725]
A2780	GI₅₀	4.4 μM Compound: 1	Cytotoxicity against human A2780 cells after 72 hrs by MTT assay Cytotoxicity against human A2780 cells after 72 hrs by MTT assay	[PMID: 20153915]
A2780	GI₅₀	4.4 μM Compound: 1	Cytotoxicity against human A2780 cells after 72 hrs by MTT assay Cytotoxicity against human A2780 cells after 72 hrs by MTT assay	[PMID: 17606377]
A-431	GI₅₀	2.9 μM Compound: 1	Cytotoxicity against human A431 cells after 72 hrs by MTT assay Cytotoxicity against human A431 cells after 72 hrs by MTT assay	[PMID: 20153915]
A-431	GI₅₀	2.9 μM Compound: 1	Cytotoxicity against human A431 cells after 72 hrs by MTT assay Cytotoxicity against human A431 cells after 72 hrs by MTT assay	[PMID: 17606377]
ADDP cell line	GI₅₀	11 μM Compound: cantharidin	Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian ADDP tumor cell lines Inhibition of growth after 72 hr continuous exposure to test compounds in Ovarian ADDP tumor cell lines	[PMID: 11881984]
ADDP cell line	IC₅₀	11 μM Compound: 1	Inhibitory activity against ovarian tumor cell line ADDP after 72 hr continuous exposure to compound Inhibitory activity against ovarian tumor cell line ADDP after 72 hr continuous exposure to compound	[PMID: 10937725]
BE(2)-C	GI₅₀	3.7 μM Compound: 1	Cytotoxicity against human BE(2)-C cells after 72 hrs by MTT assay Cytotoxicity against human BE(2)-C cells after 72 hrs by MTT assay	[PMID: 20153915]
BE(2)-C	GI₅₀	3.7 μM Compound: 1	Cytotoxicity against human BE2C cells after 72 hrs by MTT assay Cytotoxicity against human BE2C cells after 72 hrs by MTT assay	[PMID: 17606377]
Bone marrow cell	IC₅₀	6.5 μg/mL Compound: 1; CTD	Cytotoxicity against human Bone marrow cell assessed as cell growth inhibition by MTS assay Cytotoxicity against human Bone marrow cell assessed as cell growth inhibition by MTS assay	[PMID: 33454654]
DU-145	GI₅₀	2.1 μM Compound: 1	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 20153915]
DU-145	GI₅₀	2.1 μM Compound: 1	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 17606377]
HCT-116	IC₅₀	9 μM Compound: 1; CTD	Anticancer activity against human HCT-116 cells assessed as cell growth inhibition by MTT assay Anticancer activity against human HCT-116 cells assessed as cell growth inhibition by MTT assay	[PMID: 33454654]
HCT-116	IC₅₀	9 μM Compound: 1	Inhibitory activity against colon tumor cell line HCT116 after 72 hr continuous exposure to compound Inhibitory activity against colon tumor cell line HCT116 after 72 hr continuous exposure to compound	[PMID: 10937725]
Hepatocyte	IC₅₀	21 μM Compound: 1	Cytotoxicity against rat hepatocyte cells after 48 hrs by MTT assay Cytotoxicity against rat hepatocyte cells after 48 hrs by MTT assay	[PMID: 20691337]
HepG2	IC₅₀	11 μM Compound: 1	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 20691337]
HepG2	IC₅₀	19.1 μM Compound: 1; CTD	Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
HL-60	IC₅₀	2.7 μM Compound: 1; CTD	Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
HT-29	GI₅₀	3.2 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 20153915]
HT-29	GI₅₀	3.2 μM Compound: 1	Cytotoxicity against human HT29 cells after 72 hrs by MTT assay Cytotoxicity against human HT29 cells after 72 hrs by MTT assay	[PMID: 17606377]
HT-29	IC₅₀	6.4 μM Compound: 1; CTD	Anticancer activity against human HT-29 cells assessed as cell growth inhibition by MTT assay Anticancer activity against human HT-29 cells assessed as cell growth inhibition by MTT assay	[PMID: 33454654]
HT-29	GI₅₀	6.4 μM Compound: cantharidin	Inhibition of growth after 72 hr continuous exposure to test compounds in colon HT-29 tumor cell lines Inhibition of growth after 72 hr continuous exposure to test compounds in colon HT-29 tumor cell lines	[PMID: 11881984]
HT-29	IC₅₀	6.4 μM Compound: 1	Inhibitory activity against colon tumor cell line HT-29 after 72 hr continuous exposure to compound Inhibitory activity against colon tumor cell line HT-29 after 72 hr continuous exposure to compound	[PMID: 10937725]
KB 3-1	IC₅₀	2.7 μM Compound: 1; CTD	Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 33454654]
MCF7	GI₅₀	7.5 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 20153915]
MCF7	GI₅₀	7.5 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 17606377]
NCI-H460	GI₅₀	3.3 μM Compound: 1	Cytotoxicity against human H460 cells after 72 hrs by MTT assay Cytotoxicity against human H460 cells after 72 hrs by MTT assay	[PMID: 20153915]
NCI-H460	GI₅₀	3.3 μM Compound: 1	Cytotoxicity against human H460 cells after 72 hrs by MTT assay Cytotoxicity against human H460 cells after 72 hrs by MTT assay	[PMID: 17606377]
SK-HEP1	IC₅₀	34 μM Compound: 1	Cytotoxicity against human SKHEP1 cells after 48 hrs by MTT assay Cytotoxicity against human SKHEP1 cells after 48 hrs by MTT assay	[PMID: 20691337]
SW480	GI₅₀	4.5 μM Compound: 1	Cytotoxicity against human SW480 cells after 72 hrs by MTT assay Cytotoxicity against human SW480 cells after 72 hrs by MTT assay	[PMID: 20153915]
SW480	GI₅₀	4.5 μM Compound: 1	Cytotoxicity against human SW480 cells after 72 hrs by MTT assay Cytotoxicity against human SW480 cells after 72 hrs by MTT assay	[PMID: 17606377]

体外研究
(In Vitro)

Cantharidin 处理人红细胞 48 小时可显著增加膜联蛋白-V 结合细胞的百分比 (≥10 μg/mL)，显著降低前向散射 (≥25 μg/mL)，显著增加[Ca2+]i (≥25 μg /mL)，但并未显著改变神经酰胺丰度或 ROS^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

196.20

Formula

C₁₀H₁₂O₄

CAS 号

56-25-7

性状

固体

颜色

White to off-white

中文名称

斑蝥素；班蝥酸酐；斑蝥酸酐

结构分类

Others

初始来源

动物

Cantharides

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 20 mg/mL (101.94 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.0968 mL	25.4842 mL	50.9684 mL
5 mM	1.0194 mL	5.0968 mL	10.1937 mL
10 mM	0.5097 mL	2.5484 mL	5.0968 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2 mg/mL (10.19 mM); 澄清溶液

此方案可获得 ≥ 2 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.54%

选择批次：

Data Sheet (633 KB) SDS (419 KB)

COA (299 KB) HNMR (109 KB) RP-HPLC (150 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Alzoubi K, et al. Induction of Suicidal Erythrocyte Death by Cantharidin. Toxins (Basel). 2015 Jul 28;7(8):2822-34. [Content Brief]

[2]. Hsieh FS, et al. Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation. Lung Cancer. 2017 Oct;112:81-89. [Content Brief]

[3]. Huang Z, et al. Lethal and Sublethal Effects of Cantharidin on Development and Reproduction of Plutella xylostella (Lepidoptera: Plutellidae). J Econ Entomol. 2015 Jun;108(3):1054-64. [Content Brief]

[4]. Shen M, et al. Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA. Sci Rep. 2015 Jul 2;5:11836. [Content Brief]

Cantharidin 相关分类

Others

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.0968 mL	25.4842 mL	50.9684 mL	127.4210 mL
	5 mM	1.0194 mL	5.0968 mL	10.1937 mL	25.4842 mL
	10 mM	0.5097 mL	2.5484 mL	5.0968 mL	12.7421 mL
	15 mM	0.3398 mL	1.6989 mL	3.3979 mL	8.4947 mL
	20 mM	0.2548 mL	1.2742 mL	2.5484 mL	6.3711 mL
	25 mM	0.2039 mL	1.0194 mL	2.0387 mL	5.0968 mL
	30 mM	0.1699 mL	0.8495 mL	1.6989 mL	4.2474 mL
	40 mM	0.1274 mL	0.6371 mL	1.2742 mL	3.1855 mL
	50 mM	0.1019 mL	0.5097 mL	1.0194 mL	2.5484 mL
	60 mM	0.0849 mL	0.4247 mL	0.8495 mL	2.1237 mL
	80 mM	0.0637 mL	0.3186 mL	0.6371 mL	1.5928 mL
	100 mM	0.0510 mL	0.2548 mL	0.5097 mL	1.2742 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cantharidin56-25-7斑蝥素班蝥酸酐斑蝥酸酐OthersInhibitorinhibitorinhibit

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Cantharidin (Synonyms: 斑蝥素; 班蝥酸酐; 斑蝥酸酐)

Customer Review

MCE 顾客使用本产品发表的 4 篇科研文献

Cantharidin 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

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参考文献

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完整储备液配制表

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Cantharidin (Synonyms: 斑蝥素; 班蝥酸酐; 斑蝥酸酐)

Customer Review

Cantharidin 相关抗体

MCE 顾客使用本产品发表的 4 篇科研文献

Cantharidin 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

Cantharidin 相关抗体:

摩尔计算器

稀释计算器

Cantharidin 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

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