2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor Dopamine Transporter Serotonin Transporter
  4. Centanafadine

Centanafadine  (Synonyms: EB-1020)

目录号: HY-16736 纯度: 99.62%
COA 产品使用指南 技术支持

Centanafadine 是去甲肾上腺素 (NE)/多巴胺 (DA) 转运的双抑制剂，还能抑制5-羟色胺 (serotonin) 转运体，其对人 NE，DA 和5-羟色胺转运体的IC50 值分别为6 nM，38 nM 和 83 nM。

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Centanafadine Chemical Structure

Centanafadine Chemical Structure

CAS No. : 924012-43-1

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规格 价格 是否有货 数量
5 mg ￥1600
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10 mg ￥2600
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25 mg ￥5200
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Customer Review

Other Forms of Centanafadine:

Centanafadine 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

IC50 & Target

IC50: 6 nM (human NE), 38 nM (human DA), 83 nM (human serotonin)[1].
体外研究
(In Vitro)

Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters with IC50 values of 6 and 38 nM, respectively, for NE and DA transporters, Centanafadine has lesser effects on 5-HT transporter as it inhibits the reuptake of 5-HT with an IC50 value of 83 nM [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Centanafadine 相关抗体:
体内研究
(In Vivo)

In microdialysis studies, Centanafadine markedly increases NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increases DA extracellular concentrations in the striatum to 400% of baseline concentrations. Behavioral studies demonstrate that Centanafadine dose-dependently decreases immobility in the mouse tail suspension test of depression to 13% of control levels, and do not stimulate locomotor activity in adult rats in the optimal dose range. Centanafadine dose-dependently inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternally) as neonates; a well-established animal model for attention-deficit hyperactivity disorder (ADHD)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

209.29

Formula

C15H15N
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (597.26 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.7781 mL 23.8903 mL 47.7806 mL
5 mM 0.9556 mL 4.7781 mL 9.5561 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Centanafadine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7781 mL 23.8903 mL 47.7806 mL 119.4515 mL
5 mM 0.9556 mL 4.7781 mL 9.5561 mL 23.8903 mL
10 mM 0.4778 mL 2.3890 mL 4.7781 mL 11.9451 mL
15 mM 0.3185 mL 1.5927 mL 3.1854 mL 7.9634 mL
20 mM 0.2389 mL 1.1945 mL 2.3890 mL 5.9726 mL
25 mM 0.1911 mL 0.9556 mL 1.9112 mL 4.7781 mL
30 mM 0.1593 mL 0.7963 mL 1.5927 mL 3.9817 mL
40 mM 0.1195 mL 0.5973 mL 1.1945 mL 2.9863 mL
50 mM 0.0956 mL 0.4778 mL 0.9556 mL 2.3890 mL
60 mM 0.0796 mL 0.3982 mL 0.7963 mL 1.9909 mL
80 mM 0.0597 mL 0.2986 mL 0.5973 mL 1.4931 mL
100 mM 0.0478 mL 0.2389 mL 0.4778 mL 1.1945 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Centanafadine924012-43-1EB-1020EB1020EB 1020Adrenergic ReceptorDopamine TransporterSerotonin TransporterBeta ReceptorDATSLC6A35-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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