2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Crolibulin

Crolibulin  (Synonyms: EPC2407)

目录号: HY-13603 纯度: 98.96%
COA 产品使用指南

摩尔计算器

Crolibulin (EPC2407) 是一种微管 (tubulin) 蛋白聚合抑制剂，具有诱导凋亡 (apoptosis) 和抑制细胞生长的作用。Crolibulin 有抗肿瘤活性。Crolibulin 还具有心血管毒性和神经毒性。

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Crolibulin Chemical Structure

Crolibulin Chemical Structure

CAS No. : 1000852-17-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1760
In-stock
5 mg ￥1600
In-stock
10 mg ￥2800
In-stock
25 mg ￥4700
In-stock
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Crolibulin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity[1][2][3].

IC50 & Target

Tubulin polymerization[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.39 μM
Compound: Crolibulin
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 29407949]
HT-29 IC50
0.55 μM
Compound: Crolibulin
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 29407949]
MKN-45 IC50
0.17 μM
Compound: Crolibulin
Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay
Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay
[PMID: 29407949]
NCI-H460 IC50
0.03 μM
Compound: Crolibulin
Antiproliferative activity against human H460 cells after 72 hrs by MTT assay
Antiproliferative activity against human H460 cells after 72 hrs by MTT assay
[PMID: 29407949]
体外研究
(In Vitro)

Crolibulin shows significant cytotoxic activity against HT-29 cells, with an IC50 of 0.52 μM[2].
Crolibulin is active against various experimental tumors and exhibit potent inhibition of mitosis at the G2/M stage[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Crolibulin 相关抗体:
Clinical Trial
分子量

417.26

Formula

C18H17BrN4O3
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (299.57 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3966 mL 11.9829 mL 23.9659 mL
5 mM 0.4793 mL 2.3966 mL 4.7932 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.96%

COA (289 KB) HNMR (143 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

Crolibulin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3966 mL 11.9829 mL 23.9659 mL 59.9147 mL
5 mM 0.4793 mL 2.3966 mL 4.7932 mL 11.9829 mL
10 mM 0.2397 mL 1.1983 mL 2.3966 mL 5.9915 mL
15 mM 0.1598 mL 0.7989 mL 1.5977 mL 3.9943 mL
20 mM 0.1198 mL 0.5991 mL 1.1983 mL 2.9957 mL
25 mM 0.0959 mL 0.4793 mL 0.9586 mL 2.3966 mL
30 mM 0.0799 mL 0.3994 mL 0.7989 mL 1.9972 mL
40 mM 0.0599 mL 0.2996 mL 0.5991 mL 1.4979 mL
50 mM 0.0479 mL 0.2397 mL 0.4793 mL 1.1983 mL
60 mM 0.0399 mL 0.1997 mL 0.3994 mL 0.9986 mL
80 mM 0.0300 mL 0.1498 mL 0.2996 mL 0.7489 mL
100 mM 0.0240 mL 0.1198 mL 0.2397 mL 0.5991 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crolibulin1000852-17-4EPC2407EPC 2407EPC-2407Microtubule/TubulinApoptosisantineoplasticanaplasticthyroidcancercolchicine-bindingsitecellcyclearrestapoptosisantiproliferativeInhibitorinhibitorinhibit

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目录号：
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