L-Cystine  (Synonyms: L-胱氨酸)

L-Cystine is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and kidney stones^{[1][2][3][4][5][6]}

L-Cystine (83 µM 或 200 µM, 24 或 72 小时) 可有效逆转 Sulfasalazine (HY-14655) 和 Erastin (HY-15763) 在 Huh6 细胞中的生长抑制作用^[1]。
L-Cystine ( 0.8 mM, 4 小时) 在 HeLa 细胞中以 Keap1 依赖的方式诱导 Nrf2 蛋白表达含量升高^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Cystine (280 mg/kg, 口服, 11 天) 与 L-theanine (HY-15121) 一起给药，部分通过提高小鼠谷胱甘肽 (GSH) 水平和 T helper 2 (Th2) 介导的应答来增强抗原特异性 IgG 的产生^[2]。
L-Cystine (200 mg/kg, 口服, 11 天) 与 L-theanine (HY-15121) (80 mg/kg, 口服, 11 天) 在 DNP-KLH 抗原刺激后 6 小时显著降低小鼠血清 IL-10/IFN-γ 比值，但在 DNP-KLH 抗原刺激后 24 小时升高血清 IL-10/IFN-γ 比值^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

240.30

C₆H₁₂N₂O₄S₂

56-89-3

固体

White to off-white

L-胱氨酸

Room temperature in continental US; may vary elsewhere.

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Abdullah M, et al. Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc- Inhibitors[J]. Biomol Ther (Seoul). 2022 Mar 1;30(2):184-190.  [Content Brief]

  [2]. Kurihara S, et al. Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine[J]. J Vet Med Sci. 2007 Dec;69(12):1263-70.  [Content Brief]

  [3]. Dominique Bazin,et al. Cystinuria and cystinosis are usually related to L-cystine: is this really the case for cystinosis? A physicochemical investigation at micrometre and nanometre scale. Comptes Rendus. Chimie, Volume 25 (2022) no. S1, pp. 489-502.

  [4]. Greth WE, et al. Cellular accumulation of L-cystine in rat kidney cortex in vivo[J]. J Clin Invest. 1973 Feb;52(2):454-62.  [Content Brief]

  [5]. Ohtsu I, et al. Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. PLoS One. 2015 Apr 2;10(3):e0120619.  [Content Brief]

  [6]. Dai W, et al. Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture[J]. Cells. 2023 Jan 12;12(2):291.  [Content Brief]