1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. GGTase

GGTase (香叶酰基香叶转移酶)

Geranylgeranyl Transferase

GGTase 属于异戊二烯转移酶家族。它能将 GGPP 的香叶基香叶基基团转移到特定蛋白质的半胱氨酸残基上,这种翻译后修饰可以改变蛋白质的性质和功能,影响其在细胞内的定位、稳定性以及与其他分子的相互作用等。GGTase 可分为 GGTase-I、GGTase-II 和 GGTase-III。GGTase 参与细胞信号转导,通过对小 G 蛋白进行香叶基香叶基化修饰,可以激活下游信号通路,进而调控细胞的增殖、分化等过程。此外,GGTase 也参与囊泡运输和调节细胞骨架组织,可以改变细胞形态和迁移能力。其功能异常或表达改变与肿瘤、神经退行性疾病和心血管疾病密切相关[1][2]

GGTase belongs to the family of isoprenyltransferases. It can transfer the geranylgeranyl group of GGPP to the cysteine residues of specific proteins. This post-translational modification can change the properties and functions of proteins, affecting their intracellular localization, stability, and interactions with other molecules, etc. GGTase is involved in cell signal transduction. By geranylgeranylating small G proteins, it can activate downstream signaling pathways, thus regulating processes such as cell proliferation and differentiation. In addition, GGTase is also involved in vesicle transport and the regulation of the cytoskeleton organization, which can alter cell morphology and migration ability. Abnormalities in its function or changes in its expression are closely related to tumors, neurodegenerative diseases, and cardiovascular diseases[1][2].

GGTase 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16229A
    GGTI-2154 hydrochloride Inhibitor 98.93%
    GGTI-2154 hydrochloride 是一种有效和选择性的 geranylgeranyltransferase I (GGTase I) 抑制剂,IC50 值为 21 nM。GGTI-2154 hydrochloride 对 GGTase I 的选择性是 FTase (IC50=5600 nM) 的 200 倍以上。GGTI-2154 hydrochloride 可用于癌症的研究。
    GGTI-2154 hydrochloride