Neuromedin U Receptor (NMUR) (神经调节肽 U 受体)

Neuromedin U Receptor belongs to the G protein-coupled receptors family and is classified as Class A. Neuromedin U Receptor can bind the neuropeptide hormones neuromedin U and neuromedin S. Neuromedin U Receptor includes NMUR1 and NMUR2. NMUR1 is mainly expressed in peripheral tissues such as the gastrointestinal tract, while NmU-R2 is mainly expressed in the central nervous system. Neuromedin U Receptor can mediate intracellular signal transduction such as Ca²⁺ and regulate the physiological functions of multiple systems such as the gastrointestinal tract, cardiovascular system, and neuroendocrine system, for example, affecting smooth muscle contraction, blood pressure, feeding, energy balance, and stress responses. Neuromedin U Receptor is closely related to the occurrence and development of diseases such as cancer, pain, metabolic diseases, and gastrointestinal diseases, and is a highly potential target for disease treatment^[1].