2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis HDAC
  4. Triacetin

Triacetin  (Synonyms: 三醋酸甘油酯; Glyceryl triacetate; 1,2,3-Triacetoxypropane)

目录号: HY-B0896 纯度: 99.58%
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Triacetin是一种人工合成的化合物，是甘油和乙酸的三酯。

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Triacetin Chemical Structure

Triacetin Chemical Structure

CAS No. : 102-76-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥110
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100 mg ￥100
In-stock
500 mg ￥150
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1 g ￥200
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5 g ￥320
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Other Forms of Triacetin:

Triacetin 相关抗体

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Triacetin (0.25%, 24 h) 在体外诱导 HOG, Hs683, U87, U251, OG33, OG35 GBM9, GBM12, GBM34, GBM2, GBM8 和 GBM44 细胞生长停滞[1]。
Triacetin (25 mM, 24 h) 可有效抑制 U87MG (人类恶性胶质瘤) 细胞活力[2]。
Triacetin (12.5-25 mM, 24 h) 在 U87MG 细胞中诱导明显的 G2/M 细胞周期阻滞[2]。
Triacetin (12.5 mM) 诱导 GBM 癌症细胞凋亡[2]。
Triacetin (25 mM, 24 h) 降低 U87MG 细胞中 I类 和 II 类 HDAC (组蛋白脱乙酰酶) mRNA 的表达[2]。
Triacetin (12.5 mM, 24 h) 抑制 U87MG 细胞中 HDAC-8 的活性[2]。
Triacetin (12.5 mM, 24 h) 激活 mTOR 复合物下游基因，这些基因在癌症细胞代谢中起重要作用，如S6K1，mSIN1，Protor 2 和 PKCα[2]。
Triacetin (12.5 mM, 24 h) 促进有肿瘤抑制作用的 miRs 表达，这些 miRs 可以抑制 U87MG 细胞的生长，增殖，侵袭，迁移和血管生成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Triacetin 相关抗体:

Cell Viability Assay[2]

Cell Line: Human malignant glioma (U87 MG) cells
Concentration: 25 mM
Incubation Time: 24 h
Result: Inhibited the U87MG cell viability.

Cell Cycle Analysis[1]

Cell Line: Established glioma cell lines and primary tumor-derived GSCs.
Concentration: 0.25%
Incubation Time: 24 h
Result: Induced G0 growth arrest of all glioma cells, except U87, U251 and GBM (glioblastoma) 8 GSCs, without affecting Oli-Neu OPCs (oligodendrocyte progenitor cell line) or astrocytes and promoted NSC (neural stem cells) expansion.
The growth reduction of established glioma cell lines and primary tumor-derived GSCs in vitro is not due to the promotion of differentiation.

Cell Cycle Analysis[2]

Cell Line: U87 MG cells
Concentration: 12.5, 25 mM
Incubation Time: 24 h
Result: Induced 12% and 25% of sub-G1 cells and 60% and 79% of G2/M cells.

Apoptosis Analysis[2]

Cell Line: GBM cancer cells
Concentration: 12.5 mM
Incubation Time: 24 h
Result: Increased caspase-3 activity in treated GBM cancer cells.

RT-PCR[2]

Cell Line: U87MG cells
Concentration: 25 mM
Incubation Time: 24 h
Result: Decreased the classI and class II HDAC (histone deacetylase) mRNA expression.
Increased expression of S6K1, mSIN1, Protor 2, and PKCα.
Increased expression of miR-15b, miR-92, miR-101, miR-155, miR-199, miR-200, miR-223, and slight increase in expression in miR-16 and miR-17.
体内研究
(In Vivo)

Triacetin (5.0 g/kg with 10% v/v oral-sweet SF, p.o., daily, 14 days) 可增强植入少突胶质瘤 GSCs 小鼠 TMZ (Temozolomide) (HY-17364) 化疗疗效[1]。
Triacetin (5.0 g/kg with 10% v/v Ora-Sweet SF, p.o., daily, 40days) 可提高原位植入 GBM GSCs 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with oligodendroglioma-derived GSC cells [1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 14 days
Result: Significantly reduced tumor bioluminescence and increased survival but did not reduce end-point tumor volume with treatment of TMZ (Temozolomide) (HY-17364).
Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with GBM-derived GSC cells[1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 40 days
Result: Alone did not alter blood glucose, bioluminescence, or end-point tumor volume; however, increased survival.
Significantly increased survival with treatment of TMZ, with two of eight mice never redeveloping measurable flux or displaying histological signs of tumor at study termination.
分子量

218.20

Formula

C9H14O6
CAS 号
性状

液体（密度：1.16 g/cm3）

颜色

Colorless to light yellow

中文名称

三醋精；三醋酸甘油酯；三醋汀；三乙酸丙酯；三乙酸甘油酯；甘油三乙酸酯
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 2.3 mg/mL (10.54 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.5830 mL 22.9148 mL 45.8295 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Triacetin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5830 mL 22.9148 mL 45.8295 mL 114.5738 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL 22.9148 mL
10 mM 0.4583 mL 2.2915 mL 4.5830 mL 11.4574 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triacetin102-76-1Glyceryl triacetate 1,2,3-Triacetoxypropane三醋精三醋酸甘油酯三醋汀三乙酸丙酯三乙酸甘油酯甘油三乙酸酯ApoptosisHDACHistone deacetylasesmetabolismglioma cellsmiRscancerInhibitorinhibitorinhibit

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