2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Vapreotide

Vapreotide  (Synonyms: 伐普肽; RC160; BMY 41606)

目录号: HY-P0061 纯度: 98.06%
COA 产品使用指南

摩尔计算器

Vapreotide 是 神经激肽-1 (NK1) 受体拮抗剂，其 IC50 值为 330 nM。

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Custom Peptide Synthesis

Vapreotide Chemical Structure

Vapreotide Chemical Structure

CAS No. : 103222-11-3

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10 mg ￥1300
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25 mg ￥2500
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50 mg ￥4000
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Customer Review

Other Forms of Vapreotide:

Vapreotide 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Neurokinin Receptor 亚型特异性产品:

查看所有亚型
NK1 NK2 NK3

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.

IC50 & Target

NK1

 

体外研究
(In Vitro)

Vapreotide attenuates the effect of SP on calcium release in a concentration-dependent manner. The concentration required for Vapreotide to completely inhibit the effect of SP is about 100 times higher than that required for the NK1R antagonist aprepitant. The effect of Vapreotide on cell proliferation is mediated primarily by SSTR2. In order to further establish the NK1R antagonist effect of Vapreotide, U373MG cells are pretreated with SSTR2 selective antagonist CYN followed by incubation with Vapreotide and SP stimulation. The results show that pretreatment with CYN does not reverse the inhibitory effect of Vapreotide on SP-stimulated IL-8 mRNA expression. Vapreotide reduces HIV-1 replication in MDM as indicated by limited HIV gag mRNA expression compared to control MDM. In addition, SP treatment (10 μM) reverses Vapreotide inhibition of HIV-1 replication in MDM. This observation indicates that the inhibition of HIV-1 replication by Vapreotide is most likely due to its interaction with NK1R[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vapreotide 相关抗体:
Clinical Trial
分子量

1131.37

Formula

C57H70N12O9S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Val-Cys-Trp-NH2 (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

{d-Phe}-CY-{d-Trp}-KVCW-NH2 (Disulfide bridge: Cys2-Cys7)
中文名称

伐普肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (88.39 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8839 mL 4.4194 mL 8.8388 mL
5 mM 0.1768 mL 0.8839 mL 1.7678 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Cell Assay
[1]

The HEK293-NK1R cells and U373MG cells are incubated with or without Vapreotide (0, 5, 10, 20 μM) for 10 minutes and then incubated with or without SP for 3 hours. In some experiments, cells are first incubated with CYN for 10 minutes, and then Vapreotide is added and incubated for an additional 10 minutes, followed by stimulation with SP for 3 hours. Mock treated cells are used as controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Vapreotide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8839 mL 4.4194 mL 8.8388 mL 22.0971 mL
5 mM 0.1768 mL 0.8839 mL 1.7678 mL 4.4194 mL
10 mM 0.0884 mL 0.4419 mL 0.8839 mL 2.2097 mL
15 mM 0.0589 mL 0.2946 mL 0.5893 mL 1.4731 mL
20 mM 0.0442 mL 0.2210 mL 0.4419 mL 1.1049 mL
25 mM 0.0354 mL 0.1768 mL 0.3536 mL 0.8839 mL
30 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.7366 mL
40 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5524 mL
50 mM 0.0177 mL 0.0884 mL 0.1768 mL 0.4419 mL
60 mM 0.0147 mL 0.0737 mL 0.1473 mL 0.3683 mL
80 mM 0.0110 mL 0.0552 mL 0.1105 mL 0.2762 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vapreotide103222-11-3RC160 BMY 41606伐普肽RC 160RC-160BMY41606BMY 41606BMY-41606Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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