2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Amyloid-β Cholinesterase (ChE) iGluR
  4. AChE/Aβ-IN-2

AChE/Aβ-IN-2 (compound 32) 是一种有效的口服乙酰胆碱酯酶 (AChE) 抑制剂，IC50 为 86 nM，同时也是一种 NMDA 受体 (GluN1-1b/GluN2B亚基组合) 拮抗剂，IC50 为 3.876 μM。AChE/Aβ-IN-2 还能抑制 Aβ 聚集，具有良好的血脑屏障通透性和神经保护作用。AChE/Aβ-IN-2 在大鼠模型中改善认知和空间记忆障碍。

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AChE/Aβ-IN-2 Chemical Structure

AChE/Aβ-IN-2 Chemical Structure

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AChE/Aβ-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 iGluR 亚型特异性产品:

查看所有亚型
AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/Aβ-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 5.054 μM. AChE/Aβ-IN-2 also inhibits Aβ aggregation and shows good blood-brain barrier permeability. AChE/Aβ-IN-2 improves cognitive and spatial memory impairment in rats model[1].

IC50 & Target

IC50: 135 nM (AChE), 5.054 μM (NMDA receptor, GluN1-1b/GluN2B subunit)[1]
体外研究
(In Vitro)

AChE/Aβ-IN-2 (compound 33) (5-20 μM; 48 h) 抑制 Aβ1-42 (10 μM) 聚集[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/Aβ-IN-2 相关抗体:
体内研究
(In Vivo)

AChE/Aβ-IN-2 (compound 33) (10 mg/kg/d; po; 7 days) 抑制 Aβ1-42 诱导的大鼠记忆缺陷，减少 Morris 水迷宫平台区的停留时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

356.89

Formula

C20H25ClN4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/Aβ-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/Aβ-IN-2Amyloid-βCholinesterase (ChE)iGluRβ-amyloid peptideAβAbetaIonotropic glutamate receptorsblood-brain barrier permeabilityneuroprotectionInhibitorinhibitorinhibit

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