2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Cholinesterase (ChE) ROS Kinase
  4. AChE/BChE-IN-9

AChE/BChE-IN-9 (Compound 7a) 是一种有效的、具有口服活性的 AChE 和 BChE 抑制剂，对 hAChE 和 eqBChE 的 IC50 值分别为 5.74 μM 和 14.05 μM。AChE/BChE-IN-9 能够螯合铁并调节 amyloid β1-42 的聚集。AChE/BChE-IN-9 能透过血脑屏障。

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AChE/BChE-IN-9 Chemical Structure

AChE/BChE-IN-9 Chemical Structure

CAS No. : 2761542-55-4

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AChE/BChE-IN-9 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].

IC50 & Target

IC50: 5.74 μM (AChE), 14.05 μM (BChE)[1]
体内研究
(In Vivo)

AChE/BChE-IN-9 (Compound 7a) (0-25 mg/kg) improves spatial memory in cognitive deficit mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

365.38

Formula

C20H19N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BChE-IN-9 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-92761542-55-4Cholinesterase (ChE)ROS Kinaseneurodegenerative disordersAlzheimer’s diseaseacetylcholinesteraseamyloid-betaantioxidantBBBInhibitorinhibitorinhibit

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