2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-15

AChE-IN-15 (Compound 3d) 是一种可逆的人乙酰胆碱酯酶 (huAChE) (IC50=6.8 μM) 和人丁酰胆碱酯酶 (huBChE) (IC50=16.1 μM) 抑制剂。AChE-IN-15 具有显著的抗氧化效力，AChE-IN-15 可用于阿尔茨海默症的研究。

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AChE-IN-15 Chemical Structure

AChE-IN-15 Chemical Structure

CAS No. : 2242792-25-0

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AChE-IN-15 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-15 (Compound 3d) is a reversible human acetylcholinesterase (huAChE) (IC50=6.8 μM) and human butyrylcholinesterase (huBChE) (IC50=16.1 μM) inhibitor. AChE-IN-15 shows significant antioxidant potency, AChE-IN-15 can be used for the research of Alzheimer’s disease[1].

体外研究
(In Vitro)

AChE-IN-15 (compound 3d) inhibits huAChE and huBChE with IC50 values of 6.8 and 16.1 μM and inhibits RatAChE and RatBChE with IC50 values of 4.7 and 12.1μM[1].
AChE-IN-15 (compound 3d) (25 μM) inhibits self-mediated aggregation (77.9), huAChE-induced Aβ1-42 aggregation (73.6%), inhibit (78.9%) and disaggregate (64.6%) Cu2+-mediated Cu2+-mediated aggregation[1].
AChE-IN-15 (compound 3d) (25 μM) is an neuroprotective agent and displays hepatoprotective activity[1].
AChE-IN-15 (compound 3d) (25 μM) shows good blood-brain barrier (BBB) penetration[1].
AChE-IN-15 (compound 3d) (5-10 μM) displays neuroprotective effect on Aβ1-42-induced SH-SY5Y neurotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-15 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: PC12 cells
Concentration: 5 and 10 μM
Incubation Time: 24 hours
Result: Increased the cell viability to 63.9% (5 μM) and 72.3% (10 μM), respectively.
体内研究
(In Vivo)

AChE-IN-15 (compound 3d) (5-20 mg/kg; 14 days; Kunming mice) can reverse cognitive deficit.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice[1]
Dosage: 5, 10 and 20 mg/kg
Administration: for 14 days
Result: Reversed cognitive deficit induced by scopolamine.
分子量

440.45

Formula

C23H24N2O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-15 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-152242792-25-0Cholinesterase (ChE)acetylcholinesteraseAChEBChEAlzheimer’s diseaseApigenin-rivastigmine hybridsMulti-function agentsInhibitorinhibitorinhibit

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