2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Acotiamide hydrochloride

Acotiamide hydrochloride  (Synonyms: Z-338; YM443)

目录号: HY-121467A
产品使用指南

摩尔计算器

Acotiamide hydrochloride 是一种口服有效的、具有选择性和可逆性的乙酰胆酶碱酯酶 (AChE) 抑制剂,其 IC50 值为 1.79 μM。Acotiamide hydrochloride 可增强胃收缩性并加速胃排空延迟。Acotiamide hydrochloride 可用于胃动力障碍的功能性消化不良及肠道炎症的研究。

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Acotiamide hydrochloride Chemical Structure

Acotiamide hydrochloride Chemical Structure

CAS No. : 185104-11-4

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Acotiamide hydrochloride 的其他形式现货产品:

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Other Forms of Acotiamide hydrochloride:

Acotiamide hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].

IC50 & Target

IC50: 1.79 μM (AChE)[3].
体外研究
(In Vitro)

Acotiamide hydrochloride (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acotiamide hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: NR8383, macrophage
Concentration: 10, 30, 100 μM
Incubation Time: 1 hour
Result: Significantly reduced both TNF-α and IL-6 productions in LPS/MCP-1-stimulated NR8383 cells.
体内研究
(In Vivo)

Acotiamide hydrochloride (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide hydrochloride (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)[2]
Dosage: 0.3, 1, 3, 10, 30 mg/kg
Administration: Intravenous injection; once.
Result: Increased the postprandial gastric motility.
Animal Model: Male Sprague-Dawley rats (aged 6-7 weeks)[3].
Dosage: 0.83 mg/kg
Administration: Intravenous injection; once.
Result: Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
Clinical Trial
分子量

487.01

Formula

C21H31ClN4O5S
CAS 号
中文名称

盐酸阿考替胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Acotiamide hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acotiamide185104-11-4Z-338 YM443盐酸阿考替胺Z338Z 338YM443YM 443YM-443Cholinesterase (ChE)gastric motilityfunctional dyspepsiaNR8383macrophageintestinal inflammatorygastric emptyingInhibitorinhibitorinhibit

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