2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Acotiamide

Acotiamide  (Synonyms: Z-338 free base; YM443 free base)

目录号: HY-121467
产品使用指南

摩尔计算器

Acotiamide 是一种口服有效的、具有选择性和可逆性的乙酰胆酶碱酯酶 (AChE) 抑制剂,其 IC50 值为 1.79 μM。Acotiamide 可增强胃收缩性并加速胃排空延迟。Acotiamide 可用于胃动力障碍的功能性消化不良及肠道炎症的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Acotiamide monohydrochloride trihydrate 通常具有更好的水溶性和稳定性。

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Acotiamide Chemical Structure

Acotiamide Chemical Structure

CAS No. : 185106-16-5

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Acotiamide 的其他形式现货产品:

Customer Review

Other Forms of Acotiamide:

Acotiamide 相关抗体

Top Publications Citing Use of Products

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].

IC50 & Target

IC50: 1.79 μM (AChE)[3].
体外研究
(In Vitro)

Acotiamide (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acotiamide 相关抗体:

Cell Viability Assay[1]

Cell Line: NR8383, macrophage
Concentration: 10, 30, 100 μM
Incubation Time: 1 hour
Result: Significantly reduced both TNF-α and IL-6 productions in LPS/MCP-1-stimulated NR8383 cells.
体内研究
(In Vivo)

Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)[2]
Dosage: 0.3, 1, 3, 10, 30 mg/kg
Administration: Intravenous injection; once
Result: Increased the postprandial gastric motility.
Animal Model: Male Sprague-Dawley rats (aged 6-7 weeks)[3]
Dosage: 0.83 mg/kg
Administration: Intravenous injection; once.
Result: Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
Clinical Trial
分子量

450.55

Formula

C21H30N4O5S
CAS 号
中文名称

阿考替胺杂质27
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Acotiamide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acotiamide185106-16-5Z-338YM443阿考替胺杂质27Z338Z 338YM 443YM-443Cholinesterase (ChE)gastric motilityfunctional dyspepsiaNR8383macrophageintestinal inflammatorygastric emptyingInhibitorinhibitorinhibit

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