2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. ALDH1A3-IN-1

ALDH1A3-IN-1 (Compound 14) 是一个有效的 ALDH1A3 抑制剂，其 IC50 值为 0.63 µM，Ki 值为 0.46 µM。ALDH1A3-IN-1 能被用于研究前列腺癌 (prostate cancer)。

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ALDH1A3-IN-1 Chemical Structure

ALDH1A3-IN-1 Chemical Structure

CAS No. : 1695970-90-1

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10 mg ￥1450
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25 mg ￥3000
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50 mg ￥4850
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Customer Review

ALDH1A3-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Aldehyde Dehydrogenase (ALDH) 亚型特异性产品:

查看所有亚型
ALDH1 ALDH2 ALDH3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer[1].

IC50 & Target

ALDH1

 

ALDH1A3

0.63 μM (IC50)

ALDH1A1

7.08 μM (IC50)

ALDH3A1

8.00 μM (IC50)

ALDH1A3

0.46 μM (Ki)

ALDH1A3

26.92 μM (Km)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
61 μM
Compound: 14
Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
[PMID: 35212533]
LNCaP IC50
25 μM
Compound: 14
Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay
[PMID: 35212533]
PC-3 IC50
47 μM
Compound: 14
Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
[PMID: 35212533]
体外研究
(In Vitro)

ALDH1A3-IN-1 (Compound 14) (0-200 µM, 96 h) shows antiproliferative activity in prostate cancer cell lines[1].
ALDH1A3-IN-1 (0-200 µM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALDH1A3-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: PC3, LNCaP, and DU145 cells
Concentration: 12.5-200 µM
Incubation Time: 96 h
Result: Showed antiproliferative activity with IC50 values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells.

Cell Viability Assay[1]

Cell Line: Primary cells cultured at early passage from human prostate tissue biopsies
Concentration: 50 and 200 μM
Incubation Time: 72 h
Result: Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures.
分子量

284.19

Formula

C13H18BrNO
CAS 号
性状

液体（密度：1.284±0.06 g/cm3）

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (351.88 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5188 mL 17.5939 mL 35.1877 mL
5 mM 0.7038 mL 3.5188 mL 7.0375 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

ALDH1A3-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5188 mL 17.5939 mL 35.1877 mL 87.9693 mL
5 mM 0.7038 mL 3.5188 mL 7.0375 mL 17.5939 mL
10 mM 0.3519 mL 1.7594 mL 3.5188 mL 8.7969 mL
15 mM 0.2346 mL 1.1729 mL 2.3458 mL 5.8646 mL
20 mM 0.1759 mL 0.8797 mL 1.7594 mL 4.3985 mL
25 mM 0.1408 mL 0.7038 mL 1.4075 mL 3.5188 mL
30 mM 0.1173 mL 0.5865 mL 1.1729 mL 2.9323 mL
40 mM 0.0880 mL 0.4398 mL 0.8797 mL 2.1992 mL
50 mM 0.0704 mL 0.3519 mL 0.7038 mL 1.7594 mL
60 mM 0.0586 mL 0.2932 mL 0.5865 mL 1.4662 mL
80 mM 0.0440 mL 0.2199 mL 0.4398 mL 1.0996 mL
100 mM 0.0352 mL 0.1759 mL 0.3519 mL 0.8797 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALDH1A3-IN-11695970-90-1Aldehyde Dehydrogenase (ALDH)PC3LNCaPDU145Inhibitorinhibitorinhibit

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目录号：
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