2. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis
  3. Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
  4. Annonacin

Annonacin 是一种乙酰原素，它通过抑制线粒体复合物的途径而具有毒性。Annonacin 在 R406W+/+ 小鼠中增加 tau 蛋白的磷酸化。Annonacin 可充当钠/钾和肌浆网 (SERCA)ATPase 泵的抑制剂。Annonacin 对卵巢癌、宫颈癌、乳腺癌、膀胱癌和皮肤癌等多种癌细胞系均有显著杀伤作用。Annonacin 通过 Bax 和 caspase-3 相关途径诱导细胞凋亡。

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Annonacin Chemical Structure

Annonacin Chemical Structure

CAS No. : 111035-65-5

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1 mg ￥2900
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Annonacin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways[1][2][3][4].

体外研究
(In Vitro)

Annonacin (1-10 μg/mL; 0-72 小时) 可以诱导多种癌细胞系死亡，可使癌细胞阻滞在 G1 期[2]。
Annonacin (10 μg/mL; 0-24 小时) 可诱导 T24 细胞的凋亡，增强促凋亡相关基因的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Annonacin 相关抗体:

Cell Viability Assay[2]

Cell Line: T24 cells
Concentration: 1 μg/mL
Incubation Time: 0, 24, 48 and 72 h
Result: Significantly reduced cell viability. Compared with untreated controls, only 56.0%, 34.2% and 35.3% of T24 cells were alive at 24, 48 and 72 hours, respectively.

Western Blot Analysis[2]

Cell Line: T24 cells
Concentration: 10 μg/mL
Incubation Time: 1, 4, 8, 12 and 24 h
Result: Increased the levels of Bax and Bad.
Inhibited the levels of procaspase-3.
体内研究
(In Vivo)

Annonacin (0-9 mg/kg; 皮下渗透泵; 3 天) 可在 R406W+/+ 小鼠中增加 tau 蛋白的磷酸化[3]。
Annonacin (85 nM/100 μL; 局部外用; 一周两次; 22 周) 在皮肤肿瘤小鼠模型中具有抗癌作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: R406W+/+ transgenic mice[3]
Dosage: 0, 6 and 9 mg/kg/day
Administration: Subcutaneous osmotic pump; 3 days
Result: Increased the number of neurons with phosphorylated tau in the somatodendritic compartment in several brain areas.
Increased the levels of phosphorylated tau protein.
Increased in total tau protein without increase in tau mRNA, but reduced proteasomal proteolytic activity.
Increased the levels of different tau kinases.
Significantly increased the ratio of p25/p35.
Animal Model: DMBA (HY-W011845)/TPA treated female ICR mice aged 6-7 weeks old[4]
Dosage: 85 nM/100 uL
Administration: Topical application; Twice a week for 22 weeks
Result: Significantly increased the tumor latency period and reduced the tumor incidence, tumor burden and tumor volume, respectively.
Suppressed tumorigenesis manifested by significant reduction of hyperkeratosis, dermal papillae and number of keratin pearls on skin tissues.
Showed no toxicity to the liver and kidneys.
分子量

596.88

Formula

C35H64O7
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥97.0%

COA (256 KB) HNMR (189 KB)

产品使用指南 (1538 KB)
参考文献

Annonacin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Annonacin111035-65-5Potassium ChannelSodium ChannelNa+/K+ ATPaseCalcium ChannelApoptosisKcsANa channelsNa+ channelsSodium potassium pumpCa2+ channelsCa channelsAcetogenincytotoxicitymitochondrialsodiumpotassiumsarcoplasmicreticulumATPaseT24 cellsSkin cancer modelsInhibitorinhibitorinhibit

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