2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. EGFR Akt p38 MAPK ERK Apoptosis
  4. Apoptosis inducer 35

Apoptosis inducer 35 (Compound 6) 是一种多靶点抑制剂，可降低 EGFR、AKT、ERK 和 P38-MAPKα 的表达。Apoptosis inducer 35 抑制癌细胞 A549 和 Jurkat 的增殖，在 S 期阻滞细胞周期，并诱导细胞凋亡 (apoptosis)。

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Apoptosis inducer 35 Chemical Structure

Apoptosis inducer 35 Chemical Structure

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Apoptosis inducer 35 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 35 (Compound 6) is a multi-targeted inhibitor, that reduces the expressions of EGFR, AKT, ERK and P38-MAPKα. Apoptosis inducer 35 inhibits the proliferation of cancer cell A549 and Jurkat, arrests the cell cycle at S phase, and induces apoptosis[1].

分子量

541.05

Formula

C23H21ClN8O2S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 35 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 35Apoptosis inducer35Apoptosis inducer-35EGFRAktp38 MAPKERKApoptosisEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesA549JurkatWI-38Inhibitorinhibitorinhibit

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