Ardisiacrispin B

目录号: HY-N8198 纯度: 99.49%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Ardisiacrispin B在多因素耐药癌细胞中显示细胞毒性作用，通过铁中毒和凋亡细胞死亡。

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Ardisiacrispin B Chemical Structure

CAS No. : 112766-96-8

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规格	价格	是否有货
1 mg	￥1363	In-stock
5 mg	￥3000	In-stock
10 mg	￥4800	In-stock
50 mg		询价
100 mg		询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.6 μM Compound: 10, ardisiacrispin B	Cytotoxicity against human A549 cell line by MTT assay Cytotoxicity against human A549 cell line by MTT assay	[PMID: 17243725]
Bel-7402	IC₅₀	4.46 mM Compound: 9	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 22940450]
HepG2	IC₅₀	1.53 μM Compound: 12	Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HepG2	IC₅₀	20.96 mM Compound: 9	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22940450]
HL-60	IC₅₀	22.58 μM Compound: 12	Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HL-60	IC₅₀	3.2 μM Compound: 10, ardisiacrispin B	Cytotoxicity against human HL60 cell line by MTT assay Cytotoxicity against human HL60 cell line by MTT assay	[PMID: 17243725]
KB	IC₅₀	1.6 μM Compound: 12	Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
L02	IC₅₀	> 100 mM Compound: 9	Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay	[PMID: 22940450]
LNCaP	IC₅₀	9.7 μM Compound: 12	Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Lu1	IC₅₀	1.41 μM Compound: 12	Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MDA-MB-231	IC₅₀	11.76 μM Compound: 12	Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MKN-7	IC₅₀	1.27 μM Compound: 12	Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
SW480	IC₅₀	1.24 μM Compound: 12	Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]

分子量

1075.24

Formula

C₅₃H₈₆O₂₂

CAS 号

112766-96-8

性状

固体

颜色

White to off-white

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (93.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9300 mL	4.6501 mL	9.3002 mL
5 mM	0.1860 mL	0.9300 mL	1.8600 mL
10 mM	0.0930 mL	0.4650 mL	0.9300 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.49%

选择批次：

Data Sheet (599 KB) SDS (251 KB)

COA (297 KB) RP-HPLC (253 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Armelle T Mbaveng, et al. A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Phytomedicine. 2018 Apr 1;43:78-85. [Content Brief]

Ardisiacrispin B 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9300 mL	4.6501 mL	9.3002 mL	23.2506 mL
	5 mM	0.1860 mL	0.9300 mL	1.8600 mL	4.6501 mL
	10 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3251 mL
	15 mM	0.0620 mL	0.3100 mL	0.6200 mL	1.5500 mL
	20 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	25 mM	0.0372 mL	0.1860 mL	0.3720 mL	0.9300 mL
	30 mM	0.0310 mL	0.1550 mL	0.3100 mL	0.7750 mL
	40 mM	0.0233 mL	0.1163 mL	0.2325 mL	0.5813 mL
	50 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.4650 mL
	60 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.3875 mL
	80 mM	0.0116 mL	0.0581 mL	0.1163 mL	0.2906 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ardisiacrispin B112766-96-8ApoptosisFerroptosisCellcycledistributioncytotoxicityferroptosismitochondrialmembranepotentialsaponinMDRInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Ardisiacrispin B

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