2. Apoptosis Immunology/Inflammation Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling
  3. Apoptosis Bcl-2 Family Caspase COX MMP STAT
  4. Artobiloxanthone

Artobiloxanthone (Compound AA3) 具有抗肿瘤活性，特别是针对口腔鳞状细胞癌 (OSCC)。Artobiloxanthone 抑制 Akt/mTOR 通路和 STAT3 通路，从而抑制 SAS 和 T.Tn 的增殖 (IC50 分别为 11 和 22 μM)，以及癌细胞迁移。Artobiloxanthone 在 S 期阻滞细胞周期，并通过激活 caspase 3/9 诱导 OSCC 细胞凋亡 (apoptosis)。

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Artobiloxanthone Chemical Structure

Artobiloxanthone Chemical Structure

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Artobiloxanthone 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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COX COX-1 COX-2 COX-3

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9[1].

分子量

434.44

Formula

C25H22O7
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Artobiloxanthone 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ArtobiloxanthoneApoptosisBcl-2 FamilyCaspaseCOXMMPSTATCyclooxygenaseMatrix metalloproteinasesOSCCoral squamous cell carcinomaArtocarpus altilisSAST.TnHaCaTInhibitorinhibitorinhibit

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