2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. AZ683

AZ683 是一种有效的选择性3-氨基-4-苯胺喹啉 CSF1R 抑制剂。AZ683 对 CSF1R 具有较高的亲和力 (Ki=8 nM; IC50=6 nM)。AZ683 具有良好的口服生物利用度。[11C]AZ683 可作为集落刺激因子1受体 (CSF1R) 的正电子发射断层扫描 (PET) 示踪剂。

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AZ683 Chemical Structure

AZ683 Chemical Structure

CAS No. : 953798-95-3

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AZ683 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R)[1][2].

IC50 & Target

IC50: 6 nM (CSF1R)[1]
体外研究
(In Vitro)

AZ683对犬心肌细胞l型Ca通道电流的抑制IC50 3.5 μM，对人心脏NaV1.5通道的抑制IC50 14 μM [2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZ683 相关抗体:
分子量

441.47

Formula

C23H25F2N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZ683 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ683953798-95-3AZ 683AZ-683c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Rcardiovascular liabilitiescardiac myocyteoral bioavailabilityInhibitorinhibitorinhibit

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目录号：
HY-159108
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