2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. BChE-IN-13

BChE-IN-13 (Compound 17c) 是一种具有口服活性的、强效和选择性的 BChE 抑制剂，对 eqBChE 和 hBChE 的 IC50s 分别为 0.22 和 0.016 μM。BChE-IN-13 可以改善记忆和认知障碍，并可用于阿尔茨海默病 (AD) 的研究。

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BChE-IN-13 Chemical Structure

BChE-IN-13 Chemical Structure

CAS No. : 2700896-73-5

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BChE-IN-13 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC50s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research[1].

IC50 & Target

IC50: 0.22 μM (eqBChE) 0.016 μM (hBChE)[1]
体外研究
(In Vitro)

BChE-IN-13 (5-100 μM; 24 h) shows weak toxicity to SH-SY5Y, PC-12 and HT-22, and shows high mortality to BV2 cells[1].
BChE-IN-13 shows excellent blood brain barrier permeation using a parallel artificial membrane permeability assay experiment (PAMPA)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BChE-IN-13 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y, PC12, BV2 and HT-22 cells
Concentration: 5-100 μM
Incubation Time: 24 hours
Result: Showed cells viability more than 60% of SH-SY5Y, PC-12 and HT-22 even at 100 μM. Showed high mortality in BV2 cells, and reached half the mortality at 20 μM.
体内研究
(In Vivo)

BChE-IN-13 (oral gavage; 15 mg/kg; once daily; 6 d) shows the improvement in memory and cognitive function in Aβ1-42 induced AD-like disorder mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice intracerebroventricularly (icv) injected with oligomerized Aβ1-42
Dosage: 15 mg/kg
Administration: Oral gavage; 15 mg/kg; once daily; 6 days
Result: Improved the memory and cognitive function, and showed a shorter latency compared with Donepezil.
分子量

360.49

Formula

C24H28N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BChE-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-132700896-73-5Cholinesterase (ChE)memory impairmentcognitive impairmentAlzheimer’s diseaseADSH-SY5YPC12BV2HT-22Inhibitorinhibitorinhibit

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