2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. BChE-IN-4

BChE-IN-4 是一种有效的可穿过血脑屏障 BChE 抑制剂。BChE-IN-4 减轻小鼠模型中由胆碱能缺陷引起的学习和记忆缺陷。BChE-IN-4 具有阿尔茨海默病研究的潜力。

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BChE-IN-4 Chemical Structure

BChE-IN-4 Chemical Structure

CAS No. : 2304818-41-3

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BChE-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease[1].

IC50 & Target

BChE[1]
体内研究
(In Vivo)

BChE-IN-4 (compound 1) (10, 20, 30 mg/kg) attenuates learning and memory deficits caused by cholinergic deficit in AD mouse model[1].
BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)[1]
Dosage: 10, 20, 30 mg/kg
Administration: I.p.
Result: Significantly prolonged the step-through latencies in memory impaired mice.
Animal Model: 18-22 g, C57BL/6J mice[1]
Dosage: 30 mg/kg
Administration: I.p.
Result: Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task.
Animal Model: Mice[1]
Dosage: 30 mg/kg (suspended in 1% Tween 80)
Administration: I.p
Result: Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test.
分子量

383.57

Formula

C24H37N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BChE-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-42304818-41-3Cholinesterase (ChE)Alzheimer’s diseaselow cytotoxicitylearning and memory deficitsmotor effectsC57BL/6J micecross the blood-brain barrierInhibitorinhibitorinhibit

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