2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Dopamine Receptor mAChR Histamine Receptor
  4. Benztropine

Benztropine  (Synonyms: Benzatropine; Benzotropine)

目录号: HY-B0520
产品使用指南

摩尔计算器

Benztropine (Benzatropine; Benzotropine) 是一种具有口服活性的中枢性抗胆碱能剂，可用于帕金森氏病的研究。Benztropine 是一种抗组胺剂和多巴胺再摄取 (dopamine reuptake) 抑制剂。Benztropine 也是一种人 D2 多巴胺受体 (human D2 dopamine receptor) 的变构拮抗剂，并且具有抗癌作用。

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Benztropine Chemical Structure

Benztropine Chemical Structure

CAS No. : 86-13-5

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Benztropine 的其他形式现货产品:

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Other Forms of Benztropine:

Benztropine 相关抗体

Top Publications Citing Use of Products

    Benztropine purchased from MCE. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309.  [Abstract]

    p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research[1]. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].

    IC50 & Target

    D2 Receptor

     

    体外研究
    (In Vitro)

    Benztropine (0.1-10 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC50 value about 5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine reduces the size as well as the number of mammospheres significantly in a dose-dependent manne[1].
    Benztropine inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors[1].
    Benztropine induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced remyelination[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Benztropine 相关抗体:

    Cell Viability Assay[1]

    Cell Line: MDA-MB-231
    Concentration: 0, 0.1, 0.625, 1.25, 2.5, 5, 10 μM
    Incubation Time: 72 hours
    Result: Inhibited cells growth of MDA-MB-231 with an IC50 value about 5.0 μM.

    Cell Viability Assay[1]

    Cell Line: MDA-MB-231
    Concentration: 0, 1, 2, 5 μM
    Incubation Time: 4-6 days
    Result: Suppressed mammosphere formation and self-renewal capacities of BCSCs in a dose-dependent manner in vitro.
    体内研究
    (In Vivo)

    Benztropine (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Balb/c mice bearing 4T1 breast tumors[1]
    Dosage: 1.5 mg/kg
    Administration: Injection; 3 weeks
    Result: Reduced the tumor size and weight significantly without body weight changing.
    Clinical Trial
    分子量

    307.43

    Formula

    C21H25NO
    CAS 号
    中文名称

    苯甲托品
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Benztropine 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Benztropine86-13-5Benzatropine Benzotropine苯甲托品Dopamine ReceptormAChRHistamine ReceptorMuscarinic acetylcholine receptorParkinson'sdiseaseanticholinergicdopaminetransporteranti-histamineInhibitorinhibitorinhibit

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