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  3. First pass elimination

First pass elimination首过消除

释义：

First-pass elimination: After the drug absorbed through the gastrointestinal biofilm enters the liver through the hepatic portal vein, the drug can be biotransformed under the action of liver drug enzymes. The degradation or inactivation of drugs before entering the systemic circulation is called "hepatic first-pass metabolism" or "hepatic first-pass effect". The greater the hepatic first-pass effect, the more the drug is metabolized, the lower the blood drug concentration and the drug effect will be significantly affected.

肝首过消除：透过胃肠道生物膜吸收的药物经过肝门静脉入肝后，在肝药酶作用下药物可产生生物转化。药物进入体循环前的降解或失活称为“肝首过代谢”或“肝首过效应”。肝首过效应愈大，药物被代谢越多，其血药浓度也愈小，药效会受到明显的影响。

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