2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. SHP2 Phosphatase
  4. Bis(maltolato)oxovanadium(IV)

Bis(maltolato)oxovanadium(IV)  (Synonyms: BMOV)

目录号: HY-118567 纯度: 99.34%
COA 产品使用指南

摩尔计算器

Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效，可逆，竞争性和具有口服活性的光谱 蛋白酪氨酸磷酸酶 (PTP) 抑制剂。Bis(maltolato)oxovanadium(IV) 抑制 HCPTPA，PTP1B，HPTPβ 和 SHP2 的 IC50 分别为 126 nM，109 nM，26 nM 和 201 nM。Bis(maltolato)oxovanadium(IV) 是一种有效的胰岛素增敏剂。

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Bis(maltolato)oxovanadium(IV) Chemical Structure

Bis(maltolato)oxovanadium(IV) Chemical Structure

CAS No. : 38213-69-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥440
In-stock
5 mg ￥400
In-stock
10 mg ￥600
In-stock
25 mg ￥1200
In-stock
50 mg ￥1920
In-stock
100 mg ￥2913
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Bis(maltolato)oxovanadium(IV) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer[1][2].

IC50 & Target

IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)[2]
体外研究
(In Vitro)

Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bis(maltolato)oxovanadium(IV) 相关抗体:
体内研究
(In Vivo)

Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)[1]
Dosage: 0.75-3.0 mmol
Administration: Intraperitoneal injection; twice weekly; for 6 weeks
Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
分子量

317.15

Formula

C12H10O7V
CAS 号
性状

固体

颜色

Brown to black

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (78.83 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1531 mL 15.7654 mL 31.5308 mL
5 mM 0.6306 mL 3.1531 mL 6.3062 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.34%

COA (294 KB) HNMR (253 KB) LCMS (98 KB)

产品使用指南 (1538 KB)
参考文献

Bis(maltolato)oxovanadium(IV) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1531 mL 15.7654 mL 31.5308 mL 78.8271 mL
5 mM 0.6306 mL 3.1531 mL 6.3062 mL 15.7654 mL
10 mM 0.3153 mL 1.5765 mL 3.1531 mL 7.8827 mL
15 mM 0.2102 mL 1.0510 mL 2.1021 mL 5.2551 mL
20 mM 0.1577 mL 0.7883 mL 1.5765 mL 3.9414 mL
25 mM 0.1261 mL 0.6306 mL 1.2612 mL 3.1531 mL
30 mM 0.1051 mL 0.5255 mL 1.0510 mL 2.6276 mL
40 mM 0.0788 mL 0.3941 mL 0.7883 mL 1.9707 mL
50 mM 0.0631 mL 0.3153 mL 0.6306 mL 1.5765 mL
60 mM 0.0526 mL 0.2628 mL 0.5255 mL 1.3138 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis(maltolato)oxovanadium(IV)38213-69-3BMOVSHP2PhosphataseSrc homology phosphatase 2PTPN11PTPSHP-1type-2diabetesinsulinmetabolicphenotypeglucoseuptakePTP1BHCPTPAHPTPβInhibitorinhibitorinhibit

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