2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Bisphenol A-d4

Bisphenol A-d4  (Synonyms: 双酚A-d4)

目录号: HY-18260S4
产品使用指南

摩尔计算器

Bisphenol A-d4 是 Bisphenol A 的氘代物。 Bisphenol A 是一种酚类有机合成化合物，广泛用于聚碳酸酯塑料和环氧树脂的生产。Bisphenol A 是一种生殖、发育和全身毒性物质，常被归类为内分泌干扰物 (EDC)。Bisphenol A 与许多疾病有关，包括心血管疾病、呼吸系统疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。

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Bisphenol A-d<sub>4</sub> Chemical Structure

Bisphenol A-d4 Chemical Structure

CAS No. : 102438-62-0

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规格 价格 是否有货 数量
5 mg ￥1500
In-stock
10 mg ￥2400
In-stock
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Customer Review

Other Forms of Bisphenol A-d4:

Bisphenol A-d4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bisphenol A-d4 is the deuterium labeled Bisphenol A[1]. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16 IC50
0.0086 M
Compound: BAP
Compound was tested for the in vitro growth inhibition of B-16 melanoma cells after incubation for 3 days (cytotoxicity), the dose that failed to inhibit cell growth by more than 50% was determined
Compound was tested for the in vitro growth inhibition of B-16 melanoma cells after incubation for 3 days (cytotoxicity), the dose that failed to inhibit cell growth by more than 50% was determined
[PMID: 9288164]
HEK293 EC50
> 10000 nM
Compound: 3; BPA
Agonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ER-alpha-mediated transcriptional activity by luciferase reporter gene assay
Agonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ER-alpha-mediated transcriptional activity by luciferase reporter gene assay
[PMID: 30940565]
HEK293 IC50
> 10000 nM
Compound: 3; BPA
Antagonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as reduction in E2-induced ER-alpha-mediated transcriptional activity by luciferase reporter gene assay
Antagonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as reduction in E2-induced ER-alpha-mediated transcriptional activity by luciferase reporter gene assay
[PMID: 30940565]
HEK293 EC50
1689 nM
Compound: 3; BPA
Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalpha degradation by luciferase reporter gene assay
Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalpha degradation by luciferase reporter gene assay
[PMID: 30940565]
HeLa EC50
757 nM
Compound: BPA
Agonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay
Agonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay
[PMID: 31879182]
HeLa EC50
797 nM
Compound: BPA
Agonist activity at ERalpha (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay
Agonist activity at ERalpha (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay
[PMID: 31879182]
HT-22 IC50
97 μM
Compound: 33
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 36876904]
MCF7 EC50
0.29 μM
Compound: 4; BPA
Agonist activity at estrogen receptor in human MCF7 cells assessed as ERE-mediated transcriptional activity after 24 hrs by luciferase assay
Agonist activity at estrogen receptor in human MCF7 cells assessed as ERE-mediated transcriptional activity after 24 hrs by luciferase assay
[PMID: 26905830]
体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bisphenol A-d4 相关抗体:
分子量

232.31

Formula

C15H12D4O2
CAS 号
非标记 CAS
性状

固体

颜色

White to off-white

中文名称

双酚A-d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Bisphenol A-d4 相关分类

  • 摩尔计算器

  • 稀释计算器

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质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisphenol A-d4102438-62-0双酚A-d4Endogenous MetaboliteInhibitorinhibitorinhibit

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