2. GPCR/G Protein
  3. Endothelin Receptor
  4. BMS 182874 hydrochloride

BMS 182874 hydrochloride 是一种口服有效的高选择性内皮素受体 endothelin receptor ETA 拮抗剂，对 ETA 的 IC50 值和Ki 值分别为 0.150 μM 和 0.055 μM。BMS 182874 hydrochloride 能够降低 Deoxycorticosterone acetate (HY-B1472) 诱导的大鼠高血压模型的动脉压，可用于心血管疾病研究。

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BMS 182874 hydrochloride Chemical Structure

BMS 182874 hydrochloride Chemical Structure

CAS No. : 1215703-04-0

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BMS 182874 hydrochloride 的其他形式现货产品:

Other Forms of BMS 182874 hydrochloride:

BMS 182874 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS 182874 hydrochloride is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 hydrochloride reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1].

体外研究
(In Vitro)

BMS 182874 hydrochloride (dimethyla minoanalogue 11) 是 ETA 诱导的细胞内 Ca2+ 增加的有效的功能拮抗剂，在 vsm -A10 细胞中的 IC50 值为 0.150 μM, Ki 值为 0.055 μM，在兔颈动脉环中 KB 值为 0.520 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BMS 182874 hydrochloride 相关抗体:
体内研究
(In Vivo)

BMS 182874 hydrochloride (100 μM/kg；单次口服) 使动脉血压从对照水平缓慢下降 25%。给药 12 和 24 小时后，动脉血压仍比对照水平低 12%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

381.88

Formula

C17H20ClN3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS 182874 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS 1828741215703-04-0BMS182874BMS-182874Endothelin ReceptorEndothelin receptor antagonistETA AntagonisthypertensionInhibitorinhibitorinhibit

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