2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. CDK2-IN-9

CDK2-IN-9 是一种有效的 CDK2 抑制剂，IC50 为 0.63 µM。CDK2-IN-9 显示出抗增殖活性。CDK2-IN-9 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 S 和 G2/M 期。CDK2-IN-9 具有研究黑色素瘤的潜力。

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CDK2-IN-9 Chemical Structure

CDK2-IN-9 Chemical Structure

CAS No. : 2919216-33-2

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CDK2-IN-9 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK2-IN-9 is a potent CDK2 inhibitor with an IC50 of 0.63 µM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 induces apoptosis and cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma[1].

IC50 & Target[1]

CDK2

0.63 μM (IC50)

体外研究
(In Vitro)

CDK2-IN-9 (compound 5c) shows antiproliferative activity with IC50s of 3.03, 8.62, 62.52 µM for MDA-MB-435, SNB-75, WI-38 cells, respectively[1].
CDK2-IN-9 (24 h) induces apoptosis and cell cycle arrest in S and G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2-IN-9 相关抗体:

Apoptosis Analysis[1]

Cell Line: MDA-MB-435, SNB-75 cells
Concentration: 3.03for MDA-MB-435 cells, 8.62 for SNB-75 cells
Incubation Time: 24 h
Result: Induced apoptosis in MDA-MB-435 and SNB-75 cells with the percent of the total apoptosis of 28.65 and 44.22%, respectively.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435, SNB-75 cells
Concentration:
Incubation Time: 24 h
Result: Induced cell cycle arrest at S phase and G2/M.
分子量

441.89

Formula

C21H16ClN3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK2-IN-9 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-92919216-33-2CDKApoptosisCyclin dependent kinaseantiproliferativeMDA-MB-435SNB-75 cellsmelanomaapoptosisS phaseG2/MInhibitorinhibitorinhibit

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