2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-27

CDK7-IN-27 (Compound 37) 是细胞周期蛋白依赖激酶 7 (CDK7) 的选择性抑制剂，Ki 为 3 nM。CDK7-IN-27 在 G0/G1 期阻滞细胞周期。

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CDK7-IN-27 Chemical Structure

CDK7-IN-27 Chemical Structure

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CDK7-IN-27 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase[1].

IC50 & Target

CDK7

3 nM (IC50)

CDK2

19.4 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-27 (0.04-10 μM, 5 days) 抑制 MDA-MB-453 细胞增殖，EC50 为 1.49 μM[1]。
CDK7_IN-27 (1 μM, 24 h) 在小鼠和人的肝微粒体中表现出良好的代谢稳定性，半衰期分别为 38.5 分钟和 34.1 分钟[1]。
CDK7_IN-27 (0-1 μM, 24 h) 通过抑制 CDK7 抑制视网膜母细胞瘤蛋白的磷酸化，从而将细胞周期阻滞在 G0/G1 期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-27 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-453
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Inhibited phosphorylation of Rb protein at Ser780, 807/811, and Thr826.

Cell Viability Assay[1]

Cell Line: MDA-MB-453
Concentration: 0.04-10 μM
Incubation Time: 5 days
Result: Suppressed the cancer cell proliferation.
分子量

479.62

Formula

C26H37N7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK7-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-27CDKCyclin dependent kinaseMDA-MB-453TNBCtriple-negative breast cancerInhibitorinhibitorinhibit

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