2. Immunology/Inflammation MAPK/ERK Pathway Apoptosis
  3. AP-1 p38 MAPK NO Synthase TNF Receptor COX Interleukin Related
  4. Chloranthalactone B

Chloranthalactone B 是一种茚满烷型倍半萜类化合物，是可以从中药 Sarcandra glabra 中分离得到的天然产物。Chloranthalactone B 通过抑制 AP-1 和 p38 MAPK 通路来抑制炎症介质的产生。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Chloranthalactone B Chemical Structure

Chloranthalactone B Chemical Structure

CAS No. : 66395-03-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Chloranthalactone B 相关抗体

Top Publications Citing Use of Products

查看 AP-1 亚型特异性产品:

查看所有亚型
c-Fos c-Jun

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1].

体外研究
(In Vitro)

Chloranthalactone B (6.25-50 µM; 30 min) 在 LPS 刺激的 RAW264.7 细胞中具有抗炎作用并抑制 NO 产生[1]。
Chloranthalactone B (25 and 50 µM; 30 min) 抑制 LPS 处理的 RAW264.7 细胞中诱导型一氧化氮合酶 (iNOS)、环氧合酶-2 (COX-2)、肿瘤坏死因子 α (TNF-α) 和白介素-1β (IL-1β) 在细胞中的表达[1]。
Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 以浓度依赖性方式抑制 LPS 诱导的 AP-1 激活[1]。
Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 抑制 RAW264.7 细胞中 ERK、JNK 和 p38 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chloranthalactone B 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 25 and 50 µM
Incubation Time: 30 min
Result: Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner.
Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells.
分子量

244.29

Formula

C15H16O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chloranthalactone B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloranthalactone B66395-03-7AP-1p38 MAPKNO SynthaseTNF ReceptorCOXInterleukin RelatedActivator Protein 1Nitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRCyclooxygenaseILnature productstemsChinese medicinalSarcandra glabra anti-inflammatoryRAW264.7 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Chloranthalactone B
目录号：
HY-N10913
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z