2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Cimaterol

Cimaterol  (Synonyms: 西马特罗; CL 263780; (±)-2-Amino-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]benzonitrile)

目录号: HY-100935 纯度: 99.13%
COA 产品使用指南

摩尔计算器

Cimaterol (CL 263780) 是一种 β-肾上腺素能 (β-adrenergic) 激动剂。Cimaterol 与 L6 β-受体结合的 Kd 为 26 nM，与其用于刺激蛋白质合成的 EC50 (约 5 nM) 相容。

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Cimaterol Chemical Structure

Cimaterol Chemical Structure

CAS No. : 54239-37-1

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规格 价格 是否有货 数量
1 mg ￥700
In-stock
5 mg ￥1380
In-stock
10 mg ￥2200
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Cimaterol:

Cimaterol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].

IC50 & Target[1]

β-adrenoceptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 EC50
10 μM
Compound: Cimaterol
Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
[PMID: 23614528]
CHO-K1 EC50
10 μM
Compound: Cimaterol
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
[PMID: 23614528]
体外研究
(In Vitro)

Increases in protein synthesis of 12% are found with two myogenic cell lines (L6 and G8-1) on treatment for 6 hr with the beta-adrenergic agonist Cimaterol. The Kd for Cimaterol binding to the L6 beta-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].
Cimaterol induces accumulation of intracellular cAMP and increases the viability of muscle cells during proliferation stage of C2C12 cells. Cimaterol (1 μM) shows a significant increase of cAMP concentration subsequent drug exposure[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cimaterol 相关抗体:

Cell Proliferation Assay[3]

Cell Line: Mouse C2C12 myoblast cells
Concentration: 0.1 and 1 µM
Incubation Time: 8 days
Result: Fast proliferation with an increase of absorbance was noticed in treated cells compared to untreated cells at days 1, 2, and 3. From day 5 to day 8, the trend was reversed with absorbance in control cells significantly greater than that of treated cells.
体内研究
(In Vivo)

Cimaterol stimulates skeletal muscle gain in ob/ob mice[1].
Feeding Cimaterol to finishing pigs results in a slight improvement in daily gain at the 0.25 mg/kg dietary level[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: One hundred fifty crossbred pigs (55 kg)[4]
Dosage: Corn-soybean meal-based diets (.65% lysine) with 0, 0.25 and 0.5 mg/kg
Administration:
Result: Pigs fed 0.25 mg/kg with a 1-d drug withdrawal had 6.8, 7.7 and 13.5% less 10th rib fat depth and 11.1, 6.1 and 13.3% less P2 fat depth than those subjected to either a 3- or 5-d drug withdrawal or those fed the 0 mg/kg cimaterol diet (control), respectively.
Resulted in higher Warner-Bratzler shear force values and altered the proportion of saturation in some long-chain fatty acids at 0.5 mg/kg.
分子量

219.28

Formula

C12H17N3O
CAS 号
性状

固体

颜色

White to off-white

中文名称

西马特罗；喜马特罗；喜马特罗/塞曼特罗
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (570.05 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.5604 mL 22.8019 mL 45.6038 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.13%

COA (283 KB) HNMR (244 KB) RP-HPLC (255 KB) MS (68 KB)

产品使用指南 (1538 KB)
参考文献

Cimaterol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5604 mL 22.8019 mL 45.6038 mL 114.0095 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL 22.8019 mL
10 mM 0.4560 mL 2.2802 mL 4.5604 mL 11.4009 mL
15 mM 0.3040 mL 1.5201 mL 3.0403 mL 7.6006 mL
20 mM 0.2280 mL 1.1401 mL 2.2802 mL 5.7005 mL
25 mM 0.1824 mL 0.9121 mL 1.8242 mL 4.5604 mL
30 mM 0.1520 mL 0.7601 mL 1.5201 mL 3.8003 mL
40 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
50 mM 0.0912 mL 0.4560 mL 0.9121 mL 2.2802 mL
60 mM 0.0760 mL 0.3800 mL 0.7601 mL 1.9002 mL
80 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4251 mL
100 mM 0.0456 mL 0.2280 mL 0.4560 mL 1.1401 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cimaterol54239-37-1CL 263780 (±)-2-Amino-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]benzonitrile西马特罗喜马特罗喜马特罗/塞曼特罗CL263780CL-263780Adrenergic ReceptorBeta ReceptorAdrenergicenergymetabolismInhibitorinhibitorinhibit

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目录号：
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