2. Immunology/Inflammation
  3. COX NO Synthase
  4. COX-2/NO-IN-1

COX-2/NO-IN-1 是一种具有口服活性的一氧化氮合酶 (iNOS)、COX-2 表达和 NO (IC50 为 3.52 μM) 抑制剂。COX-2/NO-IN-1 具有抗炎作用。

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COX-2/NO-IN-1 Chemical Structure

COX-2/NO-IN-1 Chemical Structure

CAS No. : 2989882-91-7

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COX-2/NO-IN-1 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), COX-2 expression and NO (IC50 of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects[1].

IC50 & Target

iNOS

 

体外研究
(In Vitro)

COX-2/NO-IN-1 (Compound 13b; 2.5-10 μM) exhibits potent activity through dose-dependent inhibiting the production of nitric oxide (NO, IC50 = 3.52 μM), TNF-α and IL-6 (84.1% and 33.6%, respectively), as well as suppressing the expression of iNOS, COX-2 and TLR4 proteins in LPS-stimulated RAW264.7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2/NO-IN-1 相关抗体:
体内研究
(In Vivo)

In C57BL/6 mice with cisplatin-induced AKI, COX-2/NO-IN-1 (Compound 13b; 15-30 mg/kg; p.o.) improves kidney function, inhibits inflammatory development, and reduces pathological damage of kidney tissues[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

257.28

Formula

C15H15NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2/NO-IN-1 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/NO-IN-12989882-91-7COXNO SynthaseCyclooxygenaseNitric oxide synthasesNOSiNOSCOX-2NOTNF-αIL-6 productionanti-inflammatoryInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-146161
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