2. Immunology/Inflammation
  3. STING
  4. diABZI STING agonist-1 (tautomerism)

diABZI STING agonist-1 (tautomerism) 

目录号: HY-112921
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diABZI STING agonist-1 tautomerism (compound 3) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。

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diABZI STING agonist-1 (tautomerism) Chemical Structure

diABZI STING agonist-1 (tautomerism) Chemical Structure

CAS No. : 2138498-18-5

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Other Forms of diABZI STING agonist-1 (tautomerism):

diABZI STING agonist-1 (tautomerism) 相关抗体

Top Publications Citing Use of Products
WB
IF

    diABZI STING agonist-1 (tautomerism) purchased from MCE. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Immunofluorescence analysis of STING (green) and Flag-RAB22AQ64L (red) in stable Flag-RAB22AQ64L NCI-H1975 cells treated with or without 1 µM STING agonist-1 (diABZI) for 1 h.

    diABZI STING agonist-1 (tautomerism) purchased from MCE. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Western blot analysis of the WCL of the indicated stable 4T1 cells at the indicated time points after treatment with 10 µM STING agonist-1 (diABZI).

    diABZI STING agonist-1 (tautomerism) purchased from MCE. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Western blot analysis of EVPs isolated from HeLa, HCT116, and B16F10 cells treated with or without 10 µM STING agonist-1 (diABZI), 1 µM cGAMP, or 50 µg/mL DMXAA for 48 h.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    diABZI STING agonist-1 tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

    IC50 & Target

    EC50: 130 nM (human STNG in PBMCs) [1].
    体外研究
    (In Vitro)

    diABZI STING agonist-1 (tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    diABZI STING agonist-1 (tautomerism) 相关抗体:
    体内研究
    (In Vivo)

    diABZI STING agonist-1 (tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo[1].
    diABZI STING agonist-1 (tautomerism) (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (200 ng/ml)[1].
    diABZI STING agonist-1 (tautomerism) (intravenous injection; 1.5 mg/kg; 43 days) results in significant tumour growth inhibition and significantly improves survival (P < 0.001) with 8 out of 10 mice remaining tumor free at the end of the study on day 43[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    849.94

    Formula

    C42H51N13O7
    CAS 号
    性状

    固体

    颜色

    White to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    纯度 & 产品资料
    参考文献

    diABZI STING agonist-1 (tautomerism) 相关分类

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    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    diABZI STING agonist-1 (tautomerism)2138498-18-5STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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