2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Diorcinol

Diorcinol 是一种有效的 SHP1 抑制剂， IC50 值为 0.96 μM。Diorcinol 可以从 Aspergillus sydowii中分离得到的。Diorcinol 具有良好的血脑屏障渗透性，可用于糖尿病的研究。

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Diorcinol Chemical Structure

Diorcinol Chemical Structure

CAS No. : 20282-75-1

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Diorcinol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diorcinol is a potent SHP1 inhibitor with an IC50 value of 0.96 μM. Diorcinol can be isolated from Aspergillus sydowii. Diorcinol has good blood-brain barrier penetration and can be used for diabetes research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
31.6 μM
Compound: 52
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
HL-60 IC50
> 10 μM
Compound: 14
Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay
[PMID: 23527875]
K562 IC50
> 10 μM
Compound: 14
Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay
[PMID: 23527875]
NCI-H157 IC50
20.2 μM
Compound: 52
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
Neutrophil IC50
> 10 μg/mL
Compound: 11
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins by spectrophotometric analysis
[PMID: 23647825]
Neutrophil IC50
12.21 μM
Compound: 11
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide generation after 5 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide generation after 5 mins by spectrophotometric analysis
[PMID: 23647825]
分子量

230.26

Formula

C14H14O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

A. sydowii DL1045
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (542.86 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3429 mL 21.7146 mL 43.4292 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Diorcinol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3429 mL 21.7146 mL 43.4292 mL 108.5729 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL 21.7146 mL
10 mM 0.4343 mL 2.1715 mL 4.3429 mL 10.8573 mL
15 mM 0.2895 mL 1.4476 mL 2.8953 mL 7.2382 mL
20 mM 0.2171 mL 1.0857 mL 2.1715 mL 5.4286 mL
25 mM 0.1737 mL 0.8686 mL 1.7372 mL 4.3429 mL
30 mM 0.1448 mL 0.7238 mL 1.4476 mL 3.6191 mL
40 mM 0.1086 mL 0.5429 mL 1.0857 mL 2.7143 mL
50 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1715 mL
60 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8095 mL
80 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
100 mM 0.0434 mL 0.2171 mL 0.4343 mL 1.0857 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diorcinol20282-75-1Phosphatasechemical epigenetic regulation (CER)protein tyrosine phosphatases (PTPs)Aspergillus sydowiisecondary metabolites (SMs)Inhibitorinhibitorinhibit

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