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  4. DL-threo-PPMP hydrochloride

DL-threo-PPMP hydrochloride 是一种疟原虫 (Plasmodium falciparum) 中鞘氨醇合成酶 (sphingosine synthetase) 的抑制剂。DL-threo-PPMP hydrochloride 通过模拟鞘氨醇的底物，与鞘氨醇合成酶 (sphingosine synthetase) 结合，从而抑制其活性。这种抑制导致敏感的鞘氨醇合成酶活性的快速下降，选择性地破坏宿主细胞细胞质中 TVM 的相互连接的管状网络，这种抑制也阻断了疟原虫的增殖。DL-threo-PPMP hydrochloride 可用于疟原虫生物学和寻找新抗疟策略的研究。

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DL-threo-PPMP hydrochloride Chemical Structure

DL-threo-PPMP hydrochloride Chemical Structure

CAS No. : 139974-41-7

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DL-threo-PPMP hydrochloride 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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生物活性

DL-threo-PPMP hydrochloride is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP hydrochloride inhibits the activity of sphingosine synthetase (sphingosine synthetase) by binding to a substrate that mimics sphingosine. This inhibition leads to a rapid decline in sensitive sphingomyelin synthase (SSS) activity, selectively disrupting the interconnected tubular network of TVM in the cytoplasm of the host cell, and this inhibition also blocks the proliferation of the parasite. DL-threo-PPMP hydrochloride can be used in the study of malaria parasite biology and the search for new antimalarial strategies[1].

分子量

511.18

Formula

C29H51ClN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DL-threo-PPMP hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

DL-threo-PPMP139974-41-7ParasiteMalariaPlasmodiumSphingosine synthetaseTVMSSSInhibitorinhibitorinhibit

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