2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. (E)-Guanabenz

(E)-Guanabenz  (Synonyms: (E)-Wy-8678)

目录号: HY-W263279
产品使用指南

摩尔计算器

(E)-Guanabenz ((E)-Wy-8678) 是一种具有口服活性的中枢 α2-肾上腺素受体 (α2-adrenoceptor) 激动剂。(E)-Guanabenz 具有降血压活性，通过刺激中枢 α2- 肾上腺素受体，并减少交感神经向外周的净流出来降低血压。(E)-Guanabenz 也直接结合并抑制 GADD34，具有神经保护活性。(E)-Guanabenz 可用于高血压和帕金森病的研究。

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(E)-Guanabenz Chemical Structure

(E)-Guanabenz Chemical Structure

CAS No. : 60329-03-5

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Other Forms of (E)-Guanabenz:

(E)-Guanabenz 相关抗体

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查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2].

IC50 & Target

α adrenergic receptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
4.85 μM
Compound: Guanabenz
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
[PMID: 28230985]
HEK-293T EC50
0.09 μM
Compound: 16a
Agonist activity at human TAAR1 receptor expressed in HEK293T cells cotransfected with beta-2 receptor assessed as cAMP production by BRET assay
Agonist activity at human TAAR1 receptor expressed in HEK293T cells cotransfected with beta-2 receptor assessed as cAMP production by BRET assay
10.1039/C5MD00400D
分子量

231.08

Formula

C8H8Cl2N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E)-Guanabenz 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Guanabenz60329-03-5(E)-Wy-8678Adrenergic ReceptorBeta Receptorα2-adrenoceptorantihypertensiveneuroprotectivehypertensionParkinson diseaseInhibitorinhibitorinhibit

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