2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. Adrenergic Receptor Parasite
  4. Guanabenz

Guanabenz 是一种 α-2 肾上腺素受体激动剂，具有口服活性。Guanabenz 具有抗高血压和抗寄生虫活性。Guanabenz 干扰内质网应激信号传导，对心肌细胞具有保护作用。Guanabenz 也被用于高血压的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Guanabenz hydrochloride 通常具有更好的水溶性和稳定性。

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Guanabenz Chemical Structure

Guanabenz Chemical Structure

CAS No. : 5051-62-7

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Guanabenz 的其他形式现货产品:

Customer Review

Other Forms of Guanabenz:

Guanabenz 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].

IC50 & Target

Toxoplasma

 

体外研究
(In Vitro)

Guanabenz (0.5-50 μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability[1].
Guanabenz (0.5-50 μM, 24 h) alone not affects the UPR targets, neither on mRNA or protein level nor the phosphorylation status of eIF2a. Guanabenz also not induces GADD34 or the constitutively active form CReP[1].
Guanabenz (0.5-50 μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Guanabenz 相关抗体:

Cell Viability Assay[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect cell survival.

RT-PCR[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect levels of UPR targets.

Western Blot Analysis[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Increased the levels of low panel concentration-dependent UPR targets proteins.
体内研究
(In Vivo)

Guanabenz (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden[2].
Guanabenz (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice[2].
Guanabenz (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg
Administration: 5 mg/kg/day; i.p. ; for 3 weeks
Result: Reduced the latent brain cysts in both male and female BALB/cJ mice.
Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg; 10 mg/kg
Administration: 5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks
Result: Reversed parasite-induced hyperactivity to near-baseline levels.
Animal Model: Cats[3]
Dosage: 100 and 320 μg/kg and 1 mg/kg
Administration: 100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min
Result: Declined markedly blood pressure and nerve activity.
Clinical Trial
分子量

231.08

Formula

C8H8Cl2N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Guanabenz 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanabenz5051-62-7Adrenergic ReceptorParasiteBeta Receptorα-2-adrenoceptorantihypertensiveantiparasiticERhigh blood pressureInhibitorinhibitorinhibit

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