2. Anti-infection
  3. Parasite
  4. Endochin

Endochin 是一种抗疟剂。Endochin 抑制 T.gondii 的 IC50 为 0.003 nM。Endochin 对实验性弓形体病有抑制活性。

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Endochin Chemical Structure

Endochin Chemical Structure

CAS No. : 354155-51-4

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Endochin 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis[1][2].

IC50 & Target

Plasmodium

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
> 10 μM
Compound: Endochin
Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
[PMID: 24720377]
HepG2 IC50
> 10 μM
Compound: Endochin
Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
[PMID: 24720377]
体外研究
(In Vitro)

Endochin 抑制弓形虫细胞色素 bc1 复合物对细胞色素 c 的还原，IC50 为 8.2 nM[1]。
Endochin 抑制 T. gondii 的 IC50 为 0.003 nM[1]。
Endochin (Compound 1) 抑制 Plasmodium falciparum 分离出的多重耐药 W2 和 TM90-C2B 分离株，IC50 分别为 8.59 和 46.6 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Endochin 相关抗体:
分子量

287.40

Formula

C18H25NO2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.41%

COA (280 KB) HNMR (116 KB) LCMS (141 KB)

产品使用指南 (1538 KB)
参考文献

Endochin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endochin354155-51-4ParasiteAntimalarialT. gondiitoxoplasmosiscytochrome cTM90-C2BInhibitorinhibitorinhibit

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HY-13833
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