2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Ethyl β-carboline-3-carboxylate

Ethyl β-carboline-3-carboxylate 

目录号: HY-137494 纯度: 99.75%
COA 产品使用指南 技术支持

Ethyl β-carboline-3-carboxylate (fl-CCE) 是苯二氮卓受体的配体和短效拮抗剂。Ethyl β-carboline-3-carboxylate 单用时不会影响小脑环鸟苷酸水平，但与 Diazepam 一起服用时会显著抑制 Diazepam 上调的环鸟苷酸水平。

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Ethyl β-carboline-3-carboxylate Chemical Structure

Ethyl β-carboline-3-carboxylate Chemical Structure

CAS No. : 74214-62-3

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规格 价格 是否有货 数量
5 mg ￥200
In-stock
10 mg ￥280
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Ethyl β-carboline-3-carboxylate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam[1].

IC50 & Target

Benzodiazepine receptor[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
769-P IC50
175 μM
Compound: 4
Cytotoxicity against human renal carcinoma 769-P cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human renal carcinoma 769-P cells assessed as reduction in optical density by MTT assay
[PMID: 23279863]
A-375 IC50
> 200 μM
Compound: 4
Cytotoxicity against human malignant melanoma A375 cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human malignant melanoma A375 cells assessed as reduction in optical density by MTT assay
[PMID: 23279863]
BGC-823 IC50
> 200 μM
Compound: 4
Cytotoxicity against human gastric carcinoma BGC823 cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human gastric carcinoma BGC823 cells assessed as reduction in optical density by MTT assay
[PMID: 23279863]
KB IC50
> 200 μM
Compound: 4
Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human epidermoid carcinoma of the nasopharynx KB cells assessed as reduction in optical density by MTT assay
[PMID: 23279863]
SK-OV-3 IC50
92.6 μM
Compound: 4
Cytotoxicity against human ovary adenocarcinoma SKOV3 cells assessed as reduction in optical density by MTT assay
Cytotoxicity against human ovary adenocarcinoma SKOV3 cells assessed as reduction in optical density by MTT assay
[PMID: 23279863]
分子量

240.26

Formula

C14H12N2O2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (208.11 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1622 mL 20.8108 mL 41.6216 mL
5 mM 0.8324 mL 4.1622 mL 8.3243 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ethyl β-carboline-3-carboxylate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1622 mL 20.8108 mL 41.6216 mL 104.0539 mL
5 mM 0.8324 mL 4.1622 mL 8.3243 mL 20.8108 mL
10 mM 0.4162 mL 2.0811 mL 4.1622 mL 10.4054 mL
15 mM 0.2775 mL 1.3874 mL 2.7748 mL 6.9369 mL
20 mM 0.2081 mL 1.0405 mL 2.0811 mL 5.2027 mL
25 mM 0.1665 mL 0.8324 mL 1.6649 mL 4.1622 mL
30 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4685 mL
40 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.6013 mL
50 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0811 mL
60 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.7342 mL
80 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
100 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0405 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl β-carboline-3-carboxylate74214-62-3GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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