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FLDP-8 是一种姜黄素类似物，具有有效的抗癌作用。FLDP-8 可诱导 LN-18 细胞死亡，IC50 值为 4 μM。

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FLDP-8 Chemical Structure

FLDP-8 Chemical Structure

CAS No. : 861968-02-7

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FLDP-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC50 value of 4 μM in LN-18 cells[1].

IC50 & Target

IC50: 4 μM (LN-18 cells)[1]
体外研究
(In Vitro)

FLDP-8 (0-40 μM, 24 h) induces cell death process with an IC50 value of 4 μM in a concentration-dependent manner in LN-18 cells, which involves oxidative stress[1].
FLDP-8 (1.25 μM, 2.5 μM, 24 h) induces significant S-phase cell cycle arrest[1].
FLDP-8 (2.5 μM, 5 μM, 24 h) exhibits anti-cancer effects with anti-proliferative, anti-migratory and high potency of BBB permeable properties in Glioblastoma multiforme (GBM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FLDP-8 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: LN-18 cells and HBEC‑5i cells
Concentration: 0.625 μM -20 μM (LN‑18 cells) 1.25 μM - 40 μM (HBEC‑5i cells)
Incubation Time: 24 h
Result: Induced cytotoxicity on LN‑18 cells and HBEC‑5i cells.

Cell Cycle Analysis[1]

Cell Line: LN-18 cells
Concentration: 1.25 μM, 2.5 μM
Incubation Time: 24 h
Result: Induced arrest in S phase in a concentration-dependent manner.

Cell Invasion Assay[1]

Cell Line: LN-18 cells
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Inhibited the invasion of LN‑18 cells.

Cell Migration Assay [1]

Cell Line: LN-18 cells
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Showed a high potential in inhibiting the migration of LN-18 cells.
分子量

381.42

Formula

C22H23NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLDP-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLDP-8861968-02-7FLDP8FLDP 8Otherscurcuminoid analoguesGlioblastoma multiforme (GBM)BBBcancerLN-18HBEC5iInhibitorinhibitorinhibit

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