2. Gene
  3. ACOT8 - acyl-CoA thioesterase 8 Gene

ACOT8 - acyl-CoA thioesterase 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酰基辅酶 A 硫酯酶 8

种属: Homo sapiens

同用名: hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III

基因 ID: 10005 | 基因类型: protein coding

关于 ACOT8

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,841,721-45,857,392 (from NCBI)

This gene has 13 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in adrenal (RPKM 10.6), brain (RPKM 10.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种过氧化物酶体硫酯酶，它似乎更多地参与脂肪酸的氧化而不是它们的形成。编码的蛋白质可以与人类免疫缺陷病毒 1 蛋白 Nef 结合，并介导 Nef 诱导的 T 细胞中 CD4 的下调。[RefSeq 提供，2010 年 10 月]

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

ACOT8 基因产物(1)

mRNA Protein Name
NM_005469.4 NP_005460.2 acyl-coenzyme A thioesterase 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fatty acyl-CoA hydrolase activity IDA
IDA: 通过直接分析推断
10092594 GOA
NOT enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: 通过直接分析推断
9153233 GOA
enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: 通过直接分析推断
9299485 GOA
enables medium-chain fatty acyl-CoA hydrolase activity IDA
IDA: 通过直接分析推断
9153233 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9153233 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acyl-CoA metabolic process IDA
IDA: 通过直接分析推断
9153233 GOA
involved in dicarboxylic acid catabolic process IDA
IDA: 通过直接分析推断
16141203 GOA
involved in negative regulation of CD4 production IDA
IDA: 通过直接分析推断
9153233 GOA
involved in peroxisome fission IDA
IDA: 通过直接分析推断
15194431 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in peroxisomal matrix IDA
IDA: 通过直接分析推断
10092594 GOA
located in peroxisomal matrix IMP
IMP: 通过突变表型推断
14709540 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACOT8 蛋白结构

4HBT_3

4HBT_3: Thioesterase-like superfamily (48 - 307)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
蛋白主名 其他名称

acyl-coenzyme A thioesterase 8

HIV-Nef associated acyl-CoA thioesterase

ACOT8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ACOT8 O14734 P4HA3 Homo sapiens Q7Z4N8
Validated Y2H
32296183
Intra ACOT8 O14734 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra ACOT8 O14734 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra ACOT8 O14734 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra ACOT8 O14734 REL Homo sapiens Q04864
Y2H Array
25416956
Cross ACOT8 O14734 nef Human immunodeficiency virus P04601
Y2H
9299485
Cross ACOT8 O14734 nef Human immunodeficiency virus P04601
Pull Down
22190034
Cross ACOT8 O14734 nef Human immunodeficiency virus P04601
Pull Down
9299485
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Non-Syndromic X-Linked Intellectual Disability 14

Mrx14
Flinders Island Spotted Fever

Fisf

Thai Tick Typhus
Hypotrichosis 1

HYPT1

Hhs

Hts

Hypotrichosis Simplex

Hypotrichosis Simplex, Generalized, Hereditary

Hereditary Generalized Hypotrichosis Simplex

Generalized Hypothricosis Simplex

Hypotrichosis Simplex Hereditary

Hypotrichosis, Type 1
Alpha-Methylacyl-Coa Racemase Deficiency

Amacr Deficiency

AMACRD
Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders

Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

Disorders Of Peroxisome Biogenesis

Zellweger Spectrum

Zellweger Syndrome Spectrum

Peroxisomal Biogenesis Disorders

Pbd, Zss

Pbd-Zsd

Pbd-Zss

Pbd-Zellweger Spectrum Disorder

Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

Peroxisome Biogenesis Disorder

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorders

Zellweger Spectrum Disorder

Hyperpipecolic Acidaemia
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00180 ACOT8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ACOT8 VGNC VGNC:37519
Felis catus ACOT8 VGNC VGNC:59520
Bos taurus ACOT8 VGNC VGNC:25550
Rattus norvegicus ACOT8 RGD RGD:70368
Macaca mulatta ACOT8 VGNC VGNC:69413
Mus musculus ACOT8 MGD MGI:2158201
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