2. Gene
  3. SAE1 - SUMO1 activating enzyme subunit 1 Gene

SAE1 - SUMO1 activating enzyme subunit 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SUMO1 激活酶亚基 1

种属: Homo sapiens

同用名: AOS1; SUA1; UBLE1A; HSPC140

基因 ID: 10055 | 基因类型: protein coding

关于 SAE1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,130,835-47,210,636 (from NCBI)

This gene has 14 transcripts (splice variants), 212 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 24.6), thyroid (RPKM 21.1) and 25 other tissues.

功能概要

通过添加小蛋白 SUMO (参见 SUMO1；MIM 601912) 或 sumoylation 对蛋白质进行翻译后修饰，调节蛋白质结构和细胞内定位。 SAE1 和 UBA2 (MIM 613295) 形成一个异二聚体，作为 SUMO 激活酶用于蛋白质的 SUMO 化 (Okuma 等人，1999 [PubMed 9920803]) 。[OMIM 提供，2010 年 3 月]

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating Enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

SAE1 基因产物(3)

mRNA Protein Name
NM_001145713.2 NP_001139185.1 SUMO-activating enzyme subunit 1 isoform b
NM_001145714.2 NP_001139186.1 SUMO-activating enzyme subunit 1 isoform c
NM_005500.3 NP_005491.1 SUMO-activating enzyme subunit 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent protein binding IDA
IDA: 通过直接分析推断
10187858 GOA
contributes to SUMO activating enzyme activity IDA
IDA: 通过直接分析推断
10187858 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10187858 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
20164921 GOA
enables small protein activating enzyme binding IPI
IPI: 通过物理相互作用推断
15660128 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of protein sumoylation IDA
IDA: 通过直接分析推断
10187858 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
15660128 GOA
involved in protein sumoylation IMP
IMP: 通过突变表型推断
21968017 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SUMO activating enzyme complex IDA
IDA: 通过直接分析推断
10187858 GOA
part of SUMO activating enzyme complex IPI
IPI: 通过物理相互作用推断
15660128 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SAE1 蛋白结构

ThiF

ThiF: ThiF family (35 - 165)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
蛋白主名 其他名称

SUMO-activating enzyme subunit 1

SUMO-1 activating enzyme E1 N subunit

SAE1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SAE1 Q9UBE0 NFYC Homo sapiens Q13952-2
Y2H Prey Pooling
32296183
种属内
SAE1 Q9UBE0 NFYC Homo sapiens Q13952-2
Y2H Array
32296183
种属内
SAE1 Q9UBE0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
SAE1 Q9UBE0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
SAE1 Q9UBE0 PAX8 Homo sapiens Q06710
Y2H Prey Pooling
32296183
种属内
SAE1 Q9UBE0 PAX8 Homo sapiens Q06710
Y2H Array
32296183
种属内
SAE1 Q9UBE0 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
种属内
SAE1 Q9UBE0 PAX5 Homo sapiens Q02548
Y2H Array
32296183
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
GMS
20164921
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
X-Ray Diffraction
15660128
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
X-Ray Diffraction
20164921
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
Y2H Array
31515488
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
Sumoylase Assay
26226295
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
26496610
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
Anti Bait CoIP
17353931
种属内
SAE1 Q9UBE0 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
35271311
种属内
SAE1 Q9UBE0 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
种属内
SAE1 Q9UBE0 PAX6 Homo sapiens P26367
Y2H Array
32296183
种属内
SAE1 Q9UBE0 CRX Homo sapiens O43186
Y2H Array
32296183
种属内
SAE1 Q9UBE0 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SAE1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71643 SAE1 Protein, Human (GST) Q9UBE0 (M1-K346) ≥95%

SAE1 抗体

目录号 产品名 应用 反应物种
HY-P82102 SAE1 Antibody (YA1847) WB, ICC/IF, IP, FC Human, Rat

关联疾病

疾病名称 别名
Ogden Syndrome

OGDNS

N-Terminal Acetyltransferase Deficiency

NATD

N-Alpha-Acetyltransferase

X-Linked Malformation And Infantile Lethality Syndrome

Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis
Myositis

Idiopathic Inflammatory Myopathy

Idiopathic Inflammatory Myositis

Iim

Imm

Idiopathic Inflammatory Myopathies

Myopathy, Familial Idiopathic Inflammatory

Inflammatory Disorder Of Muscle

Idiopathic Inflammatory Myopathy, Familial

Inflammatory Myopathy, Idiopathic

Myopathies Idiopathic Inflammatory

Familial Idiopathic Inflammatory Myopathy
Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx
Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome
Childhood Type Dermatomyositis

Juvenile Dermatomyositis

Juvenile Dm

Childhood Dermatomyositis

Amyopathic Dermatomyositis

Adm

Dermatomyositis Sine Myositis

Dermatomyositis, Childhood Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12412 SAE1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SAE1 MGD MGI:1929264
Bos taurus SAE1 VGNC VGNC:34261
Felis catus SAE1 VGNC VGNC:64853
Macaca mulatta SAE1 VGNC VGNC:103860
Canis familiaris SAE1 VGNC VGNC:45843
Rattus norvegicus SAE1 RGD RGD:1306098
Others SAE1 NCBI
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