ACTR3 - actin related protein 3 Gene

中文名称：肌动蛋白相关蛋白 3

种属: Homo sapiens

同用名: ARP3

基因 ID: 10096 | 基因类型: protein coding

关于 ACTR3

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,889,934-113,962,596 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 65.6), appendix (RPKM 59.7) and 24 other tissues.

功能概要

该基因的具体功能尚未确定；然而，已知它编码的蛋白质是 ARP2/3 复合体的主要成分。该复合物位于细胞表面，通过板状足肌动蛋白组装和突起对细胞形状和运动至关重要。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2013 年 3 月]

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

ACTR3 基因产物(2)

mRNA	Protein	Name
NM_001277140.1	NP_001264069.1	actin-related protein 3 isoform 2
NM_005721.5	NP_005712.1	actin-related protein 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to actin filament binding	IDA IDA: 通过直接分析推断	11741539	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20195357	GOA
enables structural constituent of cytoskeleton	IDA IDA: 通过直接分析推断	11741539	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: 通过直接分析推断	11741539	GOA
involved in cilium assembly	IMP IMP: 通过突变表型推断	20393563	GOA
involved in positive regulation of lamellipodium assembly	IDA IDA: 通过直接分析推断	29058690	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17220302	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Arp2/3 protein complex	IDA IDA: 通过直接分析推断	11741539	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17220302	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	9230079	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16767080	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACTR3 蛋白结构

Actin

0
100
200
300
418 a.a.

蛋白主名

其他名称

actin-related protein 3

ARP3 actin related protein 3 homolog

ACTR3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ACTR3	P61158	CENPH	Homo sapiens	Q9H3R5	Y2H Array	32814053
种属内	ACTR3	P61158	CENPH	Homo sapiens	Q9H3R5	Y2H Pooling	32814053
种属内	ACTR3	P61158	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32814053
种属内	ACTR3	P61158	CDK5	Homo sapiens	Q00535	Y2H Pooling	32814053
种属内	ACTR3	P61158	CDK5	Homo sapiens	Q00535	Validated Y2H	32814053
种属内	ACTR3	P61158	CDK5	Homo sapiens	Q00535	Y2H Array	32814053
种属内	ACTR3	P61158	BRPF3	Homo sapiens	Q9ULD4-2	Y2H Pooling	32814053
种属内	ACTR3	P61158	BRPF3	Homo sapiens	Q9ULD4-2	Validated Y2H	32814053
种属内	ACTR3	P61158	BRPF3	Homo sapiens	Q9ULD4-2	Y2H Array	32814053
种属内	ACTR3	P61158	UNG	Homo sapiens	P13051-2	Y2H Pooling	32814053
种属内	ACTR3	P61158	UNG	Homo sapiens	P13051-2	Validated Y2H	32814053
种属内	ACTR3	P61158	APH1A	Homo sapiens	Q96BI3-2	Validated Y2H	32814053
种属内	ACTR3	P61158	APH1A	Homo sapiens	Q96BI3-2	Y2H Pooling	32814053
种属内	ACTR3	P61158	APH1A	Homo sapiens	Q96BI3-2	Y2H Array	32814053
种属内	ACTR3	P61158	JUND	Homo sapiens	P17535	TAP	20195357
种属内	ACTR3	P61158	HSPD1	Homo sapiens	P10809	Y2H Array	32814053
种属内	ACTR3	P61158	HSPD1	Homo sapiens	P10809	Y2H Pooling	32814053
种属内	ACTR3	P61158	HSPD1	Homo sapiens	P10809	Validated Y2H	32814053
种属内	ACTR3	P61158	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	32814053
种属内	ACTR3	P61158	STUB1	Homo sapiens	Q9UNE7	Y2H Array	32814053
种属内	ACTR3	P61158	STUB1	Homo sapiens	Q9UNE7	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ACTR3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76733	ARP3/ACTR3 Protein, Human (sf9, His-GST)	P61158 (A2-S418)	≥95%

ACTR3 抗体

目录号	产品名	应用	反应物种
HY-P82010	Actin Related Protein 3 Antibody (YA1755)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Colorectal Cancer, Hereditary Nonpolyposis, Type 2

HNPCC2	Fcc2
Coca2	Hereditary Nonpolyposis Colorectal Cancer Type 2
Colon Cancer, Familial Nonpolyposis, Type 2	Familial Nonpolyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colorectal Cancer 2	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00231	ACTR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00232	ACTR3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ACTR3	VGNC	VGNC:50033
Felis catus	ACTR3	VGNC	VGNC:59557
Macaca mulatta	ACTR3	VGNC	VGNC:69436
Canis familiaris	ACTR3	VGNC	VGNC:59392
Rattus norvegicus	ACTR3	RGD	RGD:71024
Mus musculus	ACTR3	MGD	MGI:1921367
Others	ACTR3	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ACTR3 - actin related protein 3 Gene

关于 ACTR3

功能概要

ACTR3 基因产物(2)

ACTR3 蛋白结构

ACTR3 蛋白互作信息

重组 ACTR3 蛋白

ACTR3 抗体

关联疾病

直系同源

热门区域

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ACTR3 - actin related protein 3 Gene

关于 ACTR3

功能概要

ACTR3 基因产物(2)

ACTR3 蛋白结构

ACTR3 蛋白互作信息

重组 ACTR3 蛋白

ACTR3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z