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  2. NUBP2 - NUBP iron-sulfur cluster assembly factor 2, cytosolic Gene

NUBP2 - NUBP iron-sulfur cluster assembly factor 2, cytosolic Gene

中文名称:NUBP 铁硫簇组装因子 2,胞质

种属: Homo sapiens

同用名: CFD1; CIAO6; NBP 2; NUBP1

基因 ID: 10101 | 基因类型: protein coding

关于 NUBP2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,782,960-1,789,186 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 8.3), prostate (RPKM 7.4) and 25 other tissues.

功能概要

该基因编码胞质铁硫蛋白组装所需的三磷酸腺苷 (ATP) 和金属结合蛋白。编码的蛋白质在具有核苷酸结合蛋白 1 (NUBP1) 的异四聚体中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 10 月]

This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

NUBP2 基因产物(3)

mRNA Protein Name
NM_001284501.2 NP_001271430.1 cytosolic Fe-S cluster assembly factor NUBP2 isoform 2
NM_001284502.2 NP_001271431.1 cytosolic Fe-S cluster assembly factor NUBP2 isoform 3
NM_012225.4 NP_036357.1 cytosolic Fe-S cluster assembly factor NUBP2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18573874 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NUBP2 蛋白结构

AAA_31

AAA_31: AAA domain (16 - 67)

ParA

ParA: NUBPL iron-transfer P-loop NTPase (126 - 208)

  • 0
  • 100
  • 200
  • 271 a.a.
蛋白主名 其他名称

cytosolic Fe-S cluster assembly factor NUBP2

homolog of yeast cytosolic Fe-S cluster deficient 1

NUBP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NUBP2 Q9Y5Y2 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
种属内
NUBP2 Q9Y5Y2 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
种属内
NUBP2 Q9Y5Y2 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
种属内
NUBP2 Q9Y5Y2 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
NUBP2 Q9Y5Y2 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
NUBP2 Q9Y5Y2 TGM1 Homo sapiens P22735
Y2H Array
32296183
种属内
NUBP2 Q9Y5Y2 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
种属内
NUBP2 Q9Y5Y2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
NUBP2 Q9Y5Y2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
NUBP2 Q9Y5Y2 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
种属内
NUBP2 Q9Y5Y2 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
种属内
NUBP2 Q9Y5Y2 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
NUBP2 Q9Y5Y2 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
NUBP2 Q9Y5Y2 NUBP1 Homo sapiens P53384
Anti Tag CoIP
33961781
种属内
NUBP2 Q9Y5Y2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
种属内
NUBP2 Q9Y5Y2 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 38

Spinocerebellar Ataxia Type 38

SCA38

Ataxia, Spinocerebellar, Type 38

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus NUBP2 VGNC VGNC:68585
Bos taurus NUBP2 VGNC VGNC:32316
Macaca mulatta NUBP2 VGNC VGNC:75547
Mus musculus NUBP2 MGD MGI:1347072
Canis familiaris NUBP2 VGNC VGNC:44018
Rattus norvegicus NUBP2 RGD RGD:1305113