1. Gene
  2. PPIF - peptidylprolyl isomerase F Gene

PPIF - peptidylprolyl isomerase F Gene

中文名称:肽基脯氨酰异构酶 F

种属: Homo sapiens

同用名: CYP3; CypD; CyP-M; Cyp-D

基因 ID: 10105 | 基因类型: protein coding

关于 PPIF

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:79,347,469-79,355,334 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 22 paralogues. Ubiquitous expression in adrenal (RPKM 72.6), bone marrow (RPKM 44.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是肽基-脯氨酰顺反异构酶 (PPIase) 家族的成员。 PPIases 催化寡肽中脯氨酸亚胺肽键的顺反异构化,加速蛋白质的折叠。该蛋白质是线粒体内膜中线粒体通透性转换孔的一部分。该孔的激活被认为与凋亡和坏死细胞死亡的诱导有关。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]

PPIF 基因产物(1)

mRNA Protein Name
NM_005729.4 NP_005720.1 peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: 通过直接分析推断
20676357 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22726440 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mitochondrial permeability transition pore complex IDA
IDA: 通过直接分析推断
26387735 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPIF 蛋白结构

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (51 - 204)

  • 0
  • 100
  • 207 a.a.
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase F, mitochondrial

PPIase F

PPIF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPIF P30405 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
种属内
PPIF P30405 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
种属内
PPIF P30405 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
种属内
PPIF P30405 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
种属内
PPIF P30405 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
种属内
PPIF P30405 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
种属内
PPIF P30405 PRB3 Homo sapiens Q04118
Y2H Array
32296183
种属内
PPIF P30405 PRB3 Homo sapiens Q04118
Y2H Prey Pooling
32296183
种属内
PPIF P30405 PRB3 Homo sapiens Q04118
Validated Y2H
32296183
种属内
PPIF P30405 FAM25C Homo sapiens B3EWG5
Y2H Prey Pooling
32296183
种属内
PPIF P30405 FAM25C Homo sapiens B3EWG5
Y2H Array
32296183
种属内
PPIF P30405 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
种属内
PPIF P30405 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
种属内
PPIF P30405 CMTM5 Homo sapiens Q96DZ9
Y2H Prey Pooling
25416956
种属内
PPIF P30405 CMTM5 Homo sapiens Q96DZ9
Validated Y2H
25416956
种属内
PPIF P30405 CMTM5 Homo sapiens Q96DZ9
Y2H Array
25416956
种属内
PPIF P30405 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
种属内
PPIF P30405 YIF1A Homo sapiens O95070
Y2H Array
32296183
种属内
PPIF P30405 SYPL1 Homo sapiens Q16563
Y2H Prey Pooling
32296183
种属内
PPIF P30405 SYPL1 Homo sapiens Q16563
Validated Y2H
32296183
种属内
PPIF P30405 SYPL1 Homo sapiens Q16563
Y2H Array
32296183
种属内
PPIF P30405 TP53 Homo sapiens P04637
Anti Bait CoIP
22726440
种属内
PPIF P30405 TP53 Homo sapiens P04637
Pull Down
22726440
种属内
PPIF P30405 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
种属内
PPIF P30405 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
种属内
PPIF P30405 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
种属内
PPIF P30405 ARFIP2 Homo sapiens P53365
Y2H Prey Pooling
32296183
种属内
PPIF P30405 ARFIP2 Homo sapiens P53365
Validated Y2H
32296183
种属内
PPIF P30405 ARFIP2 Homo sapiens P53365
Y2H Array
32296183
种属内
PPIF P30405 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
种属内
PPIF P30405 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
种属内
PPIF P30405 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
种属内
PPIF P30405 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
种属内
PPIF P30405 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
种属内
PPIF P30405 MAGEA11 Homo sapiens P43364
Validated Y2H
32296183
种属内
PPIF P30405 ABI2 Homo sapiens Q9NYB9
Y2H Array
25416956
种属内
PPIF P30405 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
种属内
PPIF P30405 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
种属内
PPIF P30405 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
种属内
PPIF P30405 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
种属内
PPIF P30405 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
种属内
PPIF P30405 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
SPR
32825572
种属内
PPIF P30405 SYP Homo sapiens P08247
Y2H Array
32296183
种属内
PPIF P30405 SYP Homo sapiens P08247
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PPIF 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74211 Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) P30405 (C30-S207) ≥95%

PPIF 抗体

目录号 产品名 应用 反应物种
HY-P82857 Cyclophilin F Antibody (YA2602) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy

Ullrich Disease

Ucmd

Ullrich Scleroatonic Muscular Dystrophy

Scleroatonic Muscular Dystrophy

UCMD1

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22

Lgmdr22

Muscular Dystrophy, Scleroatonic

Late Onset Scleroatonic Familial Myopathy

Congenital Muscular Dystrophy, Ullrich Type

Bethlem Myopathy 1

Bethlem Myopathy

Myopathy, Benign Congenital, With Contractures

Muscular Dystrophy, Benign Congenital

BTHLM1

Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 5

Lgmdd5

Benign Congenital Muscular Dystrophy

Benign Autosomal Dominant Myopathy

Myopathy, Bethlem

Myopathy, Bethlem, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPIF VGNC VGNC:33198
Mus musculus PPIF MGD MGI:2145814
Felis catus PPIF VGNC VGNC:97563
Rattus norvegicus PPIF RGD RGD:628670
Macaca mulatta PPIF VGNC VGNC:81510
Others PPIF NCBI