CELA3A - chymotrypsin like elastase 3A Gene

中文名称：胰凝乳蛋白酶样弹性蛋白酶 3A

种属: Homo sapiens

同用名: ELA3; ELA3A

关于 CELA3A

功能概要

弹性蛋白酶形成丝氨酸蛋白酶的一个亚家族，除了弹性蛋白之外，它还能水解许多蛋白质。人类有六个弹性蛋白酶基因，它们编码结构相似的蛋白质弹性蛋白酶 1、2、2A、2B、3A 和 3B。与其他弹性蛋白酶不同，弹性蛋白酶 3A 几乎没有弹性分解活性。与大多数人类弹性蛋白酶一样，弹性蛋白酶 3A 作为酶原从胰腺分泌，并且与其他丝氨酸蛋白酶 (例如胰蛋白酶、胰凝乳蛋白酶和激肽释放酶) 一样，它在肠道中具有消化功能。弹性蛋白酶 3A 优先在丙氨酸残基之后切割蛋白质。弹性蛋白酶 3A 也可能在胆固醇的肠道转运和代谢中发挥作用。弹性蛋白酶 3A 和弹性蛋白酶 3B 都被称为蛋白酶 E 和弹性蛋白酶 1。[RefSeq 提供，2008 年 7 月]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, Elastase 3A has little elastolytic activity. Like most of the human elastases, Elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and Kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of Cholesterol. Both Elastase 3A and Elastase 3B have been referred to as Protease E and as Elastase 1. [provided by RefSeq, Jul 2008]